Document Detail

Screening for Down's syndrome by fetal nuchal translucency measurement in a high-risk population.
MedLine Citation:
PMID:  9793186     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the discriminative capacity of nuchal translucency measurement in the detection of trisomy 21 and other chromosomal anomalies. DESIGN: Prospective cohort study. SUBJECTS: A total of 2247 women with viable singleton pregnancies between 10 and 14 weeks' gestation attending a prenatal diagnosis center for fetal karyotyping. METHODS: The fetal nuchal translucency was measured transabdominally in all women before invasive prenatal testing. RESULTS: Chromosomal abnormalities were found in 63 fetuses, including 36 with Down's syndrome. The likelihood of the presence of chromosomal abnormalities increased with larger nuchal translucency thickness. A nuchal translucency of 3 mm or more identified 25 out of 36 fetuses (69%) with trisomy 21 at the expense of a 4.0% false-positive rate. Correction of nuchal translucency measurements for differences due to variation of the measurement with gestational age, either by using the 'delta-value' or multiples of the median (MoM), did not improve the detection rate in our patient data set. CONCLUSIONS: The discriminative capacity of nuchal translucency measurement makes it a useful tool in screening for trisomy 21 and other chromosomal anomalies.
E Pajkrt; B W Mol; J M van Lith; O P Bleker; C M Bilardo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  12     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-01-08     Completed Date:  1999-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  156-62     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Amsterdam, The Netherlands.
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MeSH Terms
Cohort Studies
Down Syndrome / epidemiology,  ultrasonography*
Fetus / abnormalities*
Logistic Models
Mass Screening / methods*
Middle Aged
Neck / embryology*,  ultrasonography*
Netherlands / epidemiology
Pregnancy Outcome*
Pregnancy Trimester, First
Pregnancy, High-Risk / genetics
Prospective Studies
Sensitivity and Specificity
Ultrasonography, Prenatal*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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