Document Detail

Screening of biological activities of a series of chalcone derivatives against human pathogenic microorganisms.
MedLine Citation:
PMID:  20151389     Owner:  NLM     Status:  MEDLINE    
In an effort to develop new antimicrobial agents, a series of chalcone derivatives, 3-60, were prepared by Claisen-Schmidt condensation of appropriate acetophenones and 2-furyl methyl ketones with appropriate aromatic aldehydes, furfural, and thiophene-2-carbaldehyde in an aqueous solution of NaOH and EtOH at room temperature. The synthesized compounds were characterized by means of their IR- and NMR-spectral data, and elemental analysis. All compounds were tested for their antibacterial and antifungal activities by the disc diffusion method. For the most active compounds, also minimum inhibitory concentrations (MICs) were determined.
Isa Karaman; Hayreddin Gezegen; M Burcu G?rdere; Alparslan Dingil; Mustafa Ceylan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemistry & biodiversity     Volume:  7     ISSN:  1612-1880     ISO Abbreviation:  Chem. Biodivers.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-16     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197449     Medline TA:  Chem Biodivers     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  400-8     Citation Subset:  IM    
Department of Biology, Faculty of Arts and Sciences, Gaziosmanpasa University, TR-60250 Tokat.
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MeSH Terms
Anti-Bacterial Agents / chemistry,  isolation & purification,  pharmacology*
Antifungal Agents / chemistry,  isolation & purification,  pharmacology*
Bacteria / drug effects*
Chalcone / analogs & derivatives,  chemistry,  pharmacology*
Drug Evaluation, Preclinical*
Fungi / drug effects*
Microbial Sensitivity Tests
Structure-Activity Relationship
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antifungal Agents; 94-41-7/Chalcone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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