| Screening Assay of Residual Antibiotics in Livestock Samples by LC-MS/MS. | |
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MedLine Citation:
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PMID: 22688024 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A LC-MS/MS screening assay of multi-class antibiotics was developed for 19 residual antibiotics in livestock samples. Sample preparation employed the QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) approach using 0.5% formic acid in acetonitrile-methanol (8 : 2), with salting-out using magnesium sulfate, trisodium citrate and sodium chloride. Recovery values from 5 different livestock samples ranged from 45.5 to 121.6%, and the RSDs were under 18% at two concentration levels. The limit of quantification values of 19 analytes were under 10 µg/kg in all livestock samples, and the procedure can detect almost all analytes under the MRL. Screening capability was confirmed by employing spiked samples. This new screening assay for residual antibiotics in livestock samples is expected to be useful for routine laboratory tests. |
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Authors:
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Takayuki Nakajima; Takeo Sasamoto; Hiroshi Hayashi; Maki Kanda; Kazue Takeba; Setsuko Kanai; Tomoko Kusano; Yoko Matsushima; Ichiro Takano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan Volume: 53 ISSN: 1882-1006 ISO Abbreviation: Shokuhin Eiseigaku Zasshi Publication Date: 2012 |
Date Detail:
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Created Date: 2012-06-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0142214 Medline TA: Shokuhin Eiseigaku Zasshi Country: Japan |
Other Details:
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Languages: eng Pagination: 91-7 Citation Subset: IM |
Affiliation:
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Tokyo Metropolitan Institute of Public Health. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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