Document Detail


Screening Assay of Residual Antibiotics in Livestock Samples by LC-MS/MS.
MedLine Citation:
PMID:  22688024     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A LC-MS/MS screening assay of multi-class antibiotics was developed for 19 residual antibiotics in livestock samples. Sample preparation employed the QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) approach using 0.5% formic acid in acetonitrile-methanol (8 : 2), with salting-out using magnesium sulfate, trisodium citrate and sodium chloride. Recovery values from 5 different livestock samples ranged from 45.5 to 121.6%, and the RSDs were under 18% at two concentration levels. The limit of quantification values of 19 analytes were under 10 µg/kg in all livestock samples, and the procedure can detect almost all analytes under the MRL. Screening capability was confirmed by employing spiked samples. This new screening assay for residual antibiotics in livestock samples is expected to be useful for routine laboratory tests.
Authors:
Takayuki Nakajima; Takeo Sasamoto; Hiroshi Hayashi; Maki Kanda; Kazue Takeba; Setsuko Kanai; Tomoko Kusano; Yoko Matsushima; Ichiro Takano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan     Volume:  53     ISSN:  1882-1006     ISO Abbreviation:  Shokuhin Eiseigaku Zasshi     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0142214     Medline TA:  Shokuhin Eiseigaku Zasshi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  91-7     Citation Subset:  IM    
Affiliation:
Tokyo Metropolitan Institute of Public Health.
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