Document Detail

Scratch cytologic findings on surgically resected solitary fibrous tumors of the pleura.
MedLine Citation:
PMID:  11393069     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To ascertain the cytologic characteristics of solitary fibrous tumors of the pleura (SFTPs) on smear preparations. STUDY DESIGN: Fine needle aspiration cytology (FNAC) was initially attempted preoperatively in five cases, but the specimens were inappropriate for interpretation because only a few tumor cells were obtained. Therefore, scratch smears made at the time of operation were used. Papanicolaou and immunocytochemical staining was performed in all 10 cases, 2 of which were malignant. RESULTS: As expected, cellular tumors yielded more cells. The cytologic appearance was variable, showing spindle/bipolar, dendritic/stellate and intermediate cells. Atypical cells reminiscent of sarcoma were also present in cellular, benign tumors. Highly atypical epithelioid cells were obtained in two malignant cases. Immunocytochemically, the tumor cells were positive for CD34 and vimentin and negative for cytokeratin, regardless of histologic differences and cell shape. CONCLUSION: It seems difficult to diagnose SFTPs with certainty by FNAC, partly because the cell morphology of SFTPs resembles a wide variety of heterogeneous groups of spindle cell tumors and partly because only a few tumor cells were available in the FNAC specimens in the present study. However, a cytologic diagnosis of SFTP is possible if cytologic preparations yield CD34-positive cells with spindle/bipolar or dendritic/stellate morphology.
S Okada; Y Ebihara; M Kudo; H Serizawa; T Shimizu; M Otani; K Tsuji
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  45     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-06-06     Completed Date:  2001-07-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  372-80     Citation Subset:  IM    
Departments of Pathology and Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
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MeSH Terms
Antigens, CD34 / analysis,  immunology
Cell Nucleus / ultrastructure
Cell Size
Middle Aged
Neoplasms, Fibrous Tissue / chemistry,  diagnosis,  pathology*
Pleural Neoplasms / chemistry,  diagnosis,  pathology*
Reg. No./Substance:
0/Antigens, CD34

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