Document Detail

Scrapie-like encephalopathy in a greater kudu (Tragelaphus strepsiceros) which had not been fed ruminant-derived protein.
MedLine Citation:
PMID:  1604783     Owner:  NLM     Status:  MEDLINE    
A 19-month-old greater kudu (Tragelaphus strepsiceros), whose dam had died 15 months earlier with spongiform encephalopathy, required euthanasia after developing severe ataxia and depression with an apparently sudden onset. No macroscopic abnormalities were detected on post mortem examination but a scrapie-like spongiform encephalomyelopathy was apparent on histopathological examination of brain and segments of spinal cord. Negative stain electron microscopy of proteinase K-treated detergent extracts of tissue from the brain stem revealed the presence of scrapie associated fibrils, and a 25 to 28 kDa band comparable with that identified as abnormal PrP (prion protein) from the brains of domestic cattle with spongiform encephalopathy was detected using rabbit antiserum raised against mouse PrP. The animal was born nine months after the statutory ban on the inclusion of ruminant-derived protein in ruminant feeds and, as no other possible sources of the disease were apparent, it appears likely that the infection was acquired from the dam.
J K Kirkwood; G A Wells; A A Cunningham; S I Jackson; A C Scott; M Dawson; J W Wilesmith
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Veterinary record     Volume:  130     ISSN:  0042-4900     ISO Abbreviation:  Vet. Rec.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-15     Completed Date:  1992-07-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0031164     Medline TA:  Vet Rec     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  365-7     Citation Subset:  IM    
Institute of Zoology, Zoological Society of London.
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MeSH Terms
Animal Feed
Animals, Zoo
Brain / pathology*,  ultrastructure
Brain Diseases / etiology,  pathology,  veterinary*
Slow Virus Diseases / etiology,  pathology,  veterinary*
Spinal Cord / pathology*,  ultrastructure

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