Document Detail

Scrapie associated fibrils in the diagnosis of scrapie in sheep.
MedLine Citation:
PMID:  3604027     Owner:  NLM     Status:  MEDLINE    
Previous research has consistently demonstrated by electron microscopy the presence of scrapie associated fibrils in brain extracts prepared from mice and hamsters with clinical signs of experimental scrapie. In the present study similar fibrils were seen in all the brain extracts prepared from 11 Cheviot or Suffolk sheep with natural or experimental scrapie that had been diagnosed clinically and confirmed neuropathologically. They were not found in the brain extracts of nine sheep that did not have scrapie and which included four that had been injected with infected material but did not develop the disease. The presence of such fibrils can therefore be used as an additional diagnostic criterion for natural scrapie in sheep.
P H Gibson; R A Somerville; H Fraser; J D Foster; R H Kimberlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Veterinary record     Volume:  120     ISSN:  0042-4900     ISO Abbreviation:  Vet. Rec.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-08-10     Completed Date:  1987-08-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0031164     Medline TA:  Vet Rec     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  125-7     Citation Subset:  IM    
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MeSH Terms
Brain / ultrastructure*
Cerebral Cortex / ultrastructure
Microscopy, Electron
Scrapie / diagnosis*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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