Document Detail


A Scottish Hebridean antithrombin III deficient family--twelve years on.
MedLine Citation:
PMID:  2237388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The members of this family with ATIII deficiency have been followed for at least 12 years (1976-1989). All those with previous venous thrombo-embolism have been free from recurrence when on warfarin. During the half century 1931-1981, all 11 full term pregnancies in four affected patients were associated with venous thromboembolism; one patient was enigmatic having one full term pregnancy, without thrombotic event; between 1982 and 1989 three pregnancies have been actively managed with no clinical thrombosis. Management involved use of monitored, self administered, subcutaneous heparin before or very soon after conception and throughout pregnancy (warfarin having been stopped), planned delivery under cover of intravenous antithrombin III, reduction of heparin dosage at delivery and reintroduction of warfarin in the puerperium. The recognised hazards of heparin therapy in pregnancy did not occur. The involvement of the arterial system is reviewed. Clinical evidence provides tentative suggestions on (a) possible additional risk of cigarette smoking (b) avoidance of venography (c) avoidance of varicose vein surgery. A probe is now available for the defective antithrombin III gene in this family, but there has been no occasion yet to apply this in antenatal diagnosis.
Authors:
A S Douglas; I D Walker; N B Bennett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scottish medical journal     Volume:  35     ISSN:  0036-9330     ISO Abbreviation:  Scott Med J     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-12-07     Completed Date:  1990-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2983335R     Medline TA:  Scott Med J     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  108-13     Citation Subset:  IM    
Affiliation:
Department of Medicine and Therapeutics, University of Aberdeen, Glasgow.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / epidemiology
Adult
Antithrombin III / therapeutic use
Antithrombin III Deficiency*
Cause of Death
Drug Administration Schedule
Female
Follow-Up Studies
Genetic Counseling
Heparin / therapeutic use
Humans
Incidence
Infant, Newborn
Male
Metabolism, Inborn Errors / drug therapy,  genetics*
Pedigree
Phlebography / contraindications
Pregnancy
Pregnancy Complications, Hematologic / drug therapy
Thromboembolism / drug therapy
Warfarin / therapeutic use
Chemical
Reg. No./Substance:
81-81-2/Warfarin; 9000-94-6/Antithrombin III; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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