Document Detail


Scorpion beta-toxins and voltage-gated sodium channels: interactions and effects.
MedLine Citation:
PMID:  23276943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Scorpion beta-toxins (beta-ScTxs) modify the activity of voltage-gated sodium (Nav) channels, thereby producing neurotoxic effects in diverse organisms. For this reason, beta-ScTxs are essential tools not only for discriminating among different channel sub-types but also for studying the mechanisms of channel gating and the structure-function relationship involved in this process. This review considers both the structural and the functional implications of the beta-ScTxs after they bind to their receptor sites, in accord with their classification into a) anti-mammalian beta-ScTxs, b) anti-insect selective excitatory beta-ScTxs, c) anti-insect selective depressant beta-ScTxs and d) beta-ScTxs active on both insect and mammals Nav channels. Additionally, the molecular mechanism of toxin action by the "voltage sensor trapping" model is discussed, and the systemic effects produced by these toxins are reviewed.
Authors:
Martha Pedraza Escalona; Lourival D Possani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  572-87     Citation Subset:  IM    
Affiliation:
Instituto de Biotecnologia, UNAM, Avenida Universidad, 2001, Colonia Chamilpa, Apartado Postal 510-3, Cuernavaca 62210, Mexico. mapedmx@ibt.unam.mx
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Glutamic Acid / physiology
Humans
Insects / drug effects
Mammals
Models, Molecular
Molecular Sequence Data
Neurotoxins / pharmacology
Scorpion Venoms / chemistry,  pharmacology*
Scorpions / metabolism
Sequence Alignment
Voltage-Gated Sodium Channels / drug effects*,  physiology*
Chemical
Reg. No./Substance:
0/Neurotoxins; 0/Scorpion Venoms; 0/Voltage-Gated Sodium Channels; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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