| Sclerotic fibroma-like dermatofibroma: an uncommon distinctive variant of dermatofibroma. | |
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MedLine Citation:
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PMID: 15944929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dermatofibroma (DF) is a common benign cutaneous tumor with many variants based on alterations in the morphology and composition of its diverse elements. One very infrequent type is sclerotic fibroma-like DF (SF-DF). We report 7 new cases of SF-DF. In addition, their main clinicopathological and immunohistochemical features were compared with 14 unselected common DFs and with 3 sclerotic fibromas (SFs). Microscopically, the 7 cases of SF-DFs showed an unencapsulated, well-circumscribed, hypocellular central nodule with thick collagen bundles arranged in a storiform pattern with prominent clefts. The overlying epidermis was attenuated. The periphery of this nodule was more cellular with histopathologic features of common DF. The 7 SF-DFs patients were 4 women and 3 men with a mean (+/-SD) age of 44.8 (+/-15.5) years. These 7 patients were younger than those suffering from SFs [71.0 (+/-17.3) years; (p=0.04)] and older than those presenting common DFs [30.5 (+/-12.3) years; (p=0.03)]. Immunohistochemically, spindle cells in all 7 SF-DFs were negative for CD34 and CD99. On the contrary, the 3 cases of SF were positive for CD34 and CD99. All of the common DFs were negative for CD34 and only 4 (28.6%) of them were positive for CD99. In conclusion, SF-DF is an uncommon variant of DF with similar clinicopathological and immunohistochemical features. SF-DF shares certain histopathologic features with SF but they are immunophenotypically different. Therefore, both entities should be differentiated. |
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Authors:
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M C González-Vela; J F Val-Bernal; M Martino; M A González-López; E García-Alberdi; S Hermana |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Histology and histopathology Volume: 20 ISSN: 0213-3911 ISO Abbreviation: Histol. Histopathol. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-09 Completed Date: 2005-08-29 Revised Date: 2010-09-01 |
Medline Journal Info:
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Nlm Unique ID: 8609357 Medline TA: Histol Histopathol Country: Spain |
Other Details:
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Languages: eng Pagination: 801-6 Citation Subset: IM |
Affiliation:
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Department of Anatomical Pathology, Marques de Valdecilla University Hospital, Medical Faculty, University of Cantabria, Avda. Valdecilla 1, Santander, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, CD / analysis Antigens, CD34 / analysis Cell Adhesion Molecules / analysis Female Fibroma / pathology* Histiocytoma, Benign Fibrous / metabolism, pathology* Humans Immunohistochemistry Male Middle Aged Sclerosis Skin Neoplasms / metabolism, pathology* Vimentin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD34; 0/CD99 protein, human; 0/Cell Adhesion Molecules; 0/Vimentin |
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