| Sclerotherapy for esophageal variceal bleeding in advanced hepatocellular carcinoma: an 8-year experience in Taiwan. | |
MedLine Citation:
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PMID: 7951859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Between August 1983 and December 1991 at the Taichung Veterans General Hospital, Taiwan, 65 advanced hepatocellular carcinoma (HCC) patients with esophageal variceal bleeding received endoscopic injection sclerotherapy (EIS) and 60 such patients received conservative medical treatment without EIS. The rate of successful control of acute bleeding was 72.5% (27/40 patients) in the EIS group and 56.7% (34/60 patients) in the non-EIS group. The rebleeding rate was lower in the EIS group than in the non-EIS group (26.9% vs 73.5%). Thirty-one of the EIS and 44 of the non-EIS treatment patients, mainly Child's B and C patients, died within 2 months after the first bleeding. In the short term, EIS decreased the mortality due to esophageal variceal bleeding, but the survivors still had to face hepatic failure and tumor growth. Thus, benefits of EIS were noted on short- but not on long-term survival. The mean survival times were 2.38 months for the EIS group and 1.79 months for the non-EIS group. Since EIS had no beneficial effects on long-term survival it is doubtful whether sclerotherapy applied to esophageal variceal bleeding in patients with advanced HCC would be worthwhile, as the endoscopic procedure would only add to their suffering. |
Authors:
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C Y Cheng; G H Chen; C S Chang; C C Tseng; H K Pan; C K Huang; P F Hsieh |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of gastroenterology Volume: 29 ISSN: 0944-1174 ISO Abbreviation: J. Gastroenterol. Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1994-11-30 Completed Date: 1994-11-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 474-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Chung Shan Medical and Dental College Hospital, Taichung, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Carcinoma, Hepatocellular / complications*, mortality Esophageal and Gastric Varices / etiology, therapy* Esophagoscopy Female Follow-Up Studies Gastrointestinal Hemorrhage / etiology, therapy* Humans Liver Neoplasms / complications*, mortality Male Middle Aged Sclerosing Solutions / administration & dosage Sclerotherapy* / methods Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Sclerosing Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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