Document Detail

Sclerotherapy for esophageal variceal bleeding in advanced hepatocellular carcinoma: an 8-year experience in Taiwan.
MedLine Citation:
PMID:  7951859     Owner:  NLM     Status:  MEDLINE    
Between August 1983 and December 1991 at the Taichung Veterans General Hospital, Taiwan, 65 advanced hepatocellular carcinoma (HCC) patients with esophageal variceal bleeding received endoscopic injection sclerotherapy (EIS) and 60 such patients received conservative medical treatment without EIS. The rate of successful control of acute bleeding was 72.5% (27/40 patients) in the EIS group and 56.7% (34/60 patients) in the non-EIS group. The rebleeding rate was lower in the EIS group than in the non-EIS group (26.9% vs 73.5%). Thirty-one of the EIS and 44 of the non-EIS treatment patients, mainly Child's B and C patients, died within 2 months after the first bleeding. In the short term, EIS decreased the mortality due to esophageal variceal bleeding, but the survivors still had to face hepatic failure and tumor growth. Thus, benefits of EIS were noted on short- but not on long-term survival. The mean survival times were 2.38 months for the EIS group and 1.79 months for the non-EIS group. Since EIS had no beneficial effects on long-term survival it is doubtful whether sclerotherapy applied to esophageal variceal bleeding in patients with advanced HCC would be worthwhile, as the endoscopic procedure would only add to their suffering.
C Y Cheng; G H Chen; C S Chang; C C Tseng; H K Pan; C K Huang; P F Hsieh
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of gastroenterology     Volume:  29     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-11-30     Completed Date:  1994-11-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  474-8     Citation Subset:  IM    
Department of Internal Medicine, Chung Shan Medical and Dental College Hospital, Taichung, Taiwan.
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MeSH Terms
Acute Disease
Carcinoma, Hepatocellular / complications*,  mortality
Esophageal and Gastric Varices / etiology,  therapy*
Follow-Up Studies
Gastrointestinal Hemorrhage / etiology,  therapy*
Liver Neoplasms / complications*,  mortality
Middle Aged
Sclerosing Solutions / administration & dosage
Sclerotherapy* / methods
Survival Rate
Reg. No./Substance:
0/Sclerosing Solutions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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