Document Detail


Sclerostin and Dkk-1 in Patients with Ankylosing Spondylitis.
MedLine Citation:
PMID:  25111416     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: To determine the serum Dickkopf-related protein 1 (Dkk-1) and sclerostin levels, and their relationship with to structural damage and disease activity in patients with ankylosing spondylitis (AS), as well asnd to compare the serum Dkk-1 and sclerostin levels in the patients on or not on anreceiving and not receiving anti-TNF-α treatment. Materials and Methods: This cross-sectional study included 44 AS patients with AS and 41 healthy sexage- and -genderage-matched subjectscontrols. Demographic datas, disease activity parameters, and Bath Ankylosing Spondylitis Radiologic Index (BASRI) scores were recorded. Circulating Serum DKKkk-1 and sclerostin levels were measured using a commercially available ELISA. Results: Serum Dkk-1 levels were non-significantlylower (P > 0.05) and, sclerostin levels were significantly lower (P < 0.05) in the AS patients with AS when compared with healthy subjects than in the controls(p>0.05 and p<0.05 respectively). Dkk-1 and sclerostin levels were similar in the patients with and withoutthat did and didn't receive anti-TNF-α treatment, and in the patients with active and inactive disease (p>P > 0.05). There was non't a correlation between serumcirculating DKKkk-1 or sclerostin levels, and disease activity indices (p>P > 0.05). BASRI scores did not correlate with serum Dkk-1 levels or sclerostin(sclerostin levels (p>P > 0.05). Discussion: Sclerostin expression is impaired in AS, but this is not the case for Dkk-1. The lLack of an association of between Dkk-1 or sclerostin levels, and with anti-TNF-α agent usetreatment, disease activity indices, and radiological damage might ay indicate that neither the Dkk-1 nor sclerostin level may not be a determinantis an inducer for inflammation and radiological damage in AS patients. Pathologic bone formation in AS may be a result of might be due to molecular dysfunction of sclerostin and Dkk-1 at the cellular level.
Authors:
N Ustun; F Tok; U Kalyoncu; S Motor; R Yuksel; Ae Yagiz; H Guler; Ad Turhanoglu
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Acta reumatologica portuguesa     Volume:  39     ISSN:  0303-464X     ISO Abbreviation:  Acta Reumatol Port     Publication Date:    2014 Apr-Jun
Date Detail:
Created Date:  2014-8-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0431702     Medline TA:  Acta Reumatol Port     Country:  -    
Other Details:
Languages:  ENG     Pagination:  146-151     Citation Subset:  -    
Vernacular Title:
Sclerostin and Dkk-1 in Patients with Ankylosing Spondylitis.
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