| Sclerosis therapy of bronchial artery attenuates acute lung injury induced by burn and smoke inhalation injury in ovine model. | |
| | |
MedLine Citation:
|
PMID: 20381969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: In burned sheep, we showed more than a 10-fold increase in bronchial blood flow following smoke inhalation. It was previously reported that sclerosis of the bronchial artery prior to smoke exposure reduces the pathophysiology of the inhalation insult. We hypothesized that sclerosis of the bronchial artery after insult attenuates smoke/burn-induced acute lung injury. METHODS: Through an incision at the 4th intercostal space, a catheter was placed via the esophageal artery into the bronchial artery such that the bronchial blood flow remained intact. Acute lung injury was induced by a 40% total body surface area, 3rd degree cutaneous burn and smoke inhalation. Adult female sheep (n=18, 35.6±1.0 kg) were divided into three groups following the injury: (1) sclerosis group: 1h after injury, 4 mL of 70% ethanol was injected into bronchial artery via bronchial catheter, n=6; (2) control group: 1h after injury, an equal dose of saline was injected into bronchial artery via the bronchial catheter, n=6; (3) sham group: no injury and no treatment, n=6. The experiment was conducted in awake animals for 24 h. RESULTS: Bronchial blood flow, measured by microspheres, was significantly reduced after ethanol injection in the sclerosis group. Pulmonary function, evaluated by measurement of blood gas analysis, pulmonary mechanics, and pulmonary transvascular fluid flux, was severely impaired in the control group. However, pulmonary function was significantly improved by bronchial artery sclerosis. CONCLUSION: The results of our study clearly demonstrate a crucial role of enhanced bronchial circulation in thermal injury-related morbidity. Decreasing bronchial circulation using pharmacological agents may be an effective strategy in management of burn patients with concomitant smoke inhalation injury. |
| | |
Authors:
|
Atsumori Hamahata; Perenlei Enkhbaatar; Hiroyuki Sakurai; Motohiro Nozaki; Daniel L Traber |
Related Documents
:
|
11908509 - Penetrating vascular trauma in johannesburg, south africa. 7066779 - Vascular injuries of the limbs. 7388329 - Irradiation injury to large arteries. 20691609 - Zone i gunshot neck injury treated with common carotid and esophageal stent grafts. 8637089 - Bilateral popliteal artery injury from bumper crush injury. 3386289 - Early and late healing responses of normal canine artery to excimer laser irradiation. 17526989 - Accuracy of nonstenotic coronary atherosclerosis assessment by multi-detector computed ... 1928459 - Cellular adaptation during chronic neonatal hypoxic pulmonary hypertension. 11326229 - Facilitated coronary anastomosis using a nitinol u-clip device: bovine model. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-04-09 |
Journal Detail:
|
Title: Burns : journal of the International Society for Burn Injuries Volume: 36 ISSN: 1879-1409 ISO Abbreviation: Burns Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-01 Completed Date: 2011-04-12 Revised Date: 2011-11-01 |
Medline Journal Info:
|
Nlm Unique ID: 8913178 Medline TA: Burns Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 1042-9 Citation Subset: IM |
Copyright Information:
|
Published by Elsevier Ltd. |
Affiliation:
|
Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, 8-1 Kawada-cho Shinjuku-ku, Tokyo 162-8666, Japan. a.hamahata@prs.twmu.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Lung Injury
/
physiopathology* Animals Bronchi / blood supply* Bronchial Arteries* / physiopathology Disease Models, Animal Ethanol / therapeutic use* Female Pulmonary Circulation / drug effects Regional Blood Flow / drug effects Sclerosing Solutions / therapeutic use* Sheep, Domestic Smoke Inhalation Injury / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
|
GM060688/GM/NIGMS NIH HHS; GM66312/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Sclerosing Solutions; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparative in vitro study of honey based and silver based wound preparations on cell viability.
Next Document: Role of donor lymphocyte infusions in relapsed hematological malignancies after stem cell transplant...