Document Detail


Sclerosing cholangitis in ulcerative colitis.
MedLine Citation:
PMID:  7209379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a 5-year period 48 (14%) of 336 patients with ulcerative colitis were found to have hepatobiliary disease. The bile ducts were examined in 35 of these patients, and optimal visualization of both intra- and extra-hepatic bile ducts was obtained in 26. Duct changes compatible with sclerosing cholangitis were found in 14 patients. This finding of sclerosing cholangitis in 4% of all patients admitted with ulcerative colitis by far exceeds previous estimations on the incidence of sclerosing cholangitis in ulcerative colitis. The entire colon was usually affected, and the symptoms of the bowel disease were most often mild or moderate. The age at the onset of the colitis was usually below 20 years in patients with combined ulcerative colitis and hepatobiliary disease. In most patients the hepatobiliary disease gave no symptoms. Biochemical data and the histological findings in the liver biopsies did not distinguish between patients with hepatobiliary disease with and without sclerosing cholangitis. Our follow-up study has so far shown that most patients with sclerosing cholangitis remain asymptomatic for a considerable period of time.
Authors:
E Schrumpf; K Elgjo; O Fausa; E Gjone; F Kolmannskog; S Ritland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  15     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1980  
Date Detail:
Created Date:  1981-05-28     Completed Date:  1981-05-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  689-97     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alanine Transaminase / blood
Alkaline Phosphatase / blood
Aspartate Aminotransferases / blood
Bile Ducts, Intrahepatic / radiography*
Bilirubin / blood
Child
Cholangiography
Cholangitis / diagnosis*,  etiology
Colitis, Ulcerative / complications*
Common Bile Duct / radiography*
Common Bile Duct Diseases / diagnosis*,  etiology
Female
Humans
Liver / pathology
Male
Sclerosis
Chemical
Reg. No./Substance:
635-65-4/Bilirubin; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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