Document Detail

Scleroderma and the taxanes. Is there really a link?
MedLine Citation:
PMID:  15245529     Owner:  NLM     Status:  MEDLINE    
Scleroderma has been associated with exposure to many substances in the past ranging from vinyl chloride to silicon dioxide. In recent years there have been a number of case reports linking modern chemotherapy agents, such as the taxanes to the development of scleroderma like changes. We present a further case of scleroderma in association with chemotherapy but question the role of some of the agents previously implicated. A brief review of the current literature is included.
P B J Farrant; P S Mortimer; M Gore
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  29     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-12     Completed Date:  2004-09-07     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  360-2     Citation Subset:  IM    
Department of Dermatology, St George's Hospital, The Royal Marsden Hospital, London, UK.
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MeSH Terms
Antineoplastic Agents, Phytogenic / administration & dosage,  adverse effects*
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Drug Eruptions / etiology*,  pathology
Middle Aged
Paclitaxel / administration & dosage,  adverse effects*
Scleroderma, Systemic / chemically induced*,  pathology
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 33069-62-4/Paclitaxel

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