| Scleroderma and chronic myeloid leukemia: a sheer coincidence, a consequence of long lasting D-penicillamine therapy or a plausible relationship of both diseases? | |
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MedLine Citation:
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PMID: 16871407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systemic sclerosis is a chronic multisystem disorder of unknown etiology characterized by the involvement of skin and visceral organs caused by an accumulation of collagen. It has been reported that the incidence of solid and hematological malignancy increased in systemic sclerosis. Multiple myeloma and chronic lymphocytic leukemia are the most common hematological malignancies seen in patients with systemic sclerosis. Chronic myeloid leukemia (CML) has only rarely been reported so far. We here report a case with CREST (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactly, telangiectasia) who developed CML 7 years after the onset of CREST. Ours is the second case with CML developing after the onset of CREST in the literature. We also briefly discuss the possible tendency to hematological malignancy in systemic sclerosis. |
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Authors:
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Timuçin Kaşifoğlu; Cengiz Korkmaz; Sule Yaşar; Zafer Gülbaş |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-07-27 |
Journal Detail:
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Title: Rheumatology international Volume: 27 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2007-01-09 Completed Date: 2007-10-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 175-7 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Department of Internal Medicine, Eskişehir Osmangazi University Medical Faculty, Vişnelik Mah. Alifuat Güven C. Akasya Sok. 11/11, 26020 Eskişehir, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antirheumatic Agents
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adverse effects* CREST Syndrome / complications*, drug therapy Female Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive / chemically induced, complications* Middle Aged Penicillamine / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 52-67-5/Penicillamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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