Document Detail


Scleroderma and chronic myeloid leukemia: a sheer coincidence, a consequence of long lasting D-penicillamine therapy or a plausible relationship of both diseases?
MedLine Citation:
PMID:  16871407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Systemic sclerosis is a chronic multisystem disorder of unknown etiology characterized by the involvement of skin and visceral organs caused by an accumulation of collagen. It has been reported that the incidence of solid and hematological malignancy increased in systemic sclerosis. Multiple myeloma and chronic lymphocytic leukemia are the most common hematological malignancies seen in patients with systemic sclerosis. Chronic myeloid leukemia (CML) has only rarely been reported so far. We here report a case with CREST (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactly, telangiectasia) who developed CML 7 years after the onset of CREST. Ours is the second case with CML developing after the onset of CREST in the literature. We also briefly discuss the possible tendency to hematological malignancy in systemic sclerosis.
Authors:
Timuçin Kaşifoğlu; Cengiz Korkmaz; Sule Yaşar; Zafer Gülbaş
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-07-27
Journal Detail:
Title:  Rheumatology international     Volume:  27     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-09     Completed Date:  2007-10-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  175-7     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, Department of Internal Medicine, Eskişehir Osmangazi University Medical Faculty, Vişnelik Mah. Alifuat Güven C. Akasya Sok. 11/11, 26020 Eskişehir, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Antirheumatic Agents / adverse effects*
CREST Syndrome / complications*,  drug therapy
Female
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / chemically induced,  complications*
Middle Aged
Penicillamine / adverse effects*
Chemical
Reg. No./Substance:
0/Antirheumatic Agents; 52-67-5/Penicillamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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