| Sclerochorioretinal abnormalities in hypercholesterolemic rabbits treated with rosiglitazone. | |
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MedLine Citation:
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PMID: 20795574 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: To evaluate early retinal, choroidal, and scleral abnormalities induced by a hypercholesterolemic diet and the prevention of these abnormalities after oral administration of rosiglitazone in rabbits. MATERIALS AND METHODS: Fifty-four New Zealand rabbits were divided into four study groups: control group, normal diet; group 1, hypercholesterolemic diet; group 2, hypercholesterolemic diet associated with daily administration of 3 mg of rosiglitazone from day 14 after beginning the diet; and group 3, hypercholesterolemic diet associated with daily administration of 3 mg of rosiglitazone since the beginning of the experiment. Sclera and choroid underwent histologic and histomorphometric analyses. Retina underwent immunohistochemical analysis with anti-calretinin and anti-glial fibrillary acidic protein (GFAP) antibodies. RESULTS: No abnormalities were observed in the control group. Group 1 had significant increases in scleral and choroidal thicknesses compared with the control group (P < .01) and group 3 (P < .05). Group 1 presented significant increases in immunoreactivity (P < .001) to the anti-calretinin antibody compared with the other groups. Groups 2 and 3 had significant (P < .002) increases in calretinin immunoreactivity compared with the control group. GFAP was negative in all groups. CONCLUSION: The hypercholesterolemic diet induced early retinal, choroidal, and scleral abnormalities. Rosiglitazone preserved the structural anatomy. |
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Authors:
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Rogil José de Almeida Torres; Cristina Muccioli; Maurício Maia; Lucia Noronha; Andréa Luchini; Alexandre Alessi; Márcia Olandoski; Michel Eid Farah; Dalton Bertolin Précoma |
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Publication Detail:
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Type: Journal Article Date: 2010-07-29 |
Journal Detail:
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Title: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye Volume: 41 ISSN: 1938-2375 ISO Abbreviation: Ophthalmic Surg Lasers Imaging Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101155780 Medline TA: Ophthalmic Surg Lasers Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 562-71 Citation Subset: IM |
Copyright Information:
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Copyright 2010, SLACK Incorporated. |
Affiliation:
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Ophthalmology Department, Universidade Federal de São Paulo-SP Hospital Angelina Caron, Curitiba, PR, Brazil. rjat@terra.com.br |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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