| Sclerocarya birrea (Anacardiaceae) stem-bark extract corrects glycaemia in diabetic rats and acts on beta-cells by enhancing glucose-stimulated insulin secretion. | |
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MedLine Citation:
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PMID: 20061513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sclerocarya birrea is a plant widely used as traditional medication for the treatment of diabetes in sub-Saharan regions. However, the mechanism of action is unknown and only hypoglycaemic effects of S. birrea extract (SBE) in diabetic rats have been reported to date. Here, we tested aqueous extracts of S. birrea on insulin-secreting INS-1E cells and isolated rat islets. Following 24 h of treatment at 5 microg/ml, the extract markedly potentiated glucose-stimulated insulin secretion. Neither basal insulin release nor non-nutrient stimulation was affected. The potentiation of the secretory response at stimulatory glucose appeared after 12 h of treatment. No acute effects were observed and, at the effective concentration, SBE was safe regarding cell integrity and differentiation. The mechanism of action of the SBE was related to glucose metabolism as both ATP generation and glucose oxidation were enhanced following the 24-h treatment. In streptozotocin-induced diabetic rats, SBE administration corrected glycaemia and restored plasma insulin levels after 2 weeks of treatment. These data show direct action of S. birrea on insulin-secreting cells and favour further delineation for use of the plant in the management of diabetes. |
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Authors:
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Ivonne Gis?le Makom Ndifossap; Francesca Frigerio; Marina Casimir; Florence Ngueguim Tsofack; Etienne Dongo; Pierre Kamtchouing; Th?ophile Dimo; Pierre Maechler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-08 |
Journal Detail:
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Title: The Journal of endocrinology Volume: 205 ISSN: 1479-6805 ISO Abbreviation: J. Endocrinol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 79-86 Citation Subset: IM |
Affiliation:
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, Geneva 4, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Anacardiaceae* Animals Cell Line, Tumor Diabetes Mellitus, Experimental / chemically induced, drug therapy*, metabolism Disease Models, Animal Glucose / metabolism, pharmacology* Hyperglycemia / drug therapy*, metabolism Insulin / metabolism* Insulin-Secreting Cells / drug effects, metabolism* Insulinoma / metabolism, pathology Male Pancreatic Neoplasms / metabolism, pathology Plant Bark Plant Extracts / pharmacology, therapeutic use* Plant Stems Rats Rats, Wistar Streptozocin |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts; 11061-68-0/Insulin; 18883-66-4/Streptozocin; 50-99-7/Glucose; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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