Document Detail


Scleral anisotropy and its effects on the mechanical response of the optic nerve head.
MedLine Citation:
PMID:  23188256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper presents a computational modeling study of the effects of the collagen fiber structure on the mechanical response of the sclera and the adjacent optic nerve head (ONH). A specimen-specific inverse finite element method was developed to determine the material properties of two human sclera subjected to full-field inflation experiments. A distributed fiber model was applied to describe the anisotropic elastic behavior of the sclera. The model directly incorporated wide-angle X-ray scattering measurements of the anisotropic collagen structure. The converged solution of the inverse method was used in micromechanical studies of the mechanical anisotropy of the sclera at different scales. The effects of the scleral collagen fiber structure on the ONH deformation were evaluated by progressively filtering out local anisotropic features. It was found that the majority of the midposterior sclera could be described as isotropic without significantly affecting the mechanical response of the tissues of the ONH. In contrast, removing local anisotropic features in the peripapillary sclera produced significant changes in scleral canal expansion and lamina cribrosa deformation. Local variations in the collagen structure of the peripapillary sclera significantly influenced the mechanical response of the ONH.
Authors:
Baptiste Coudrillier; Craig Boote; Harry A Quigley; Thao D Nguyen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-28
Journal Detail:
Title:  Biomechanics and modeling in mechanobiology     Volume:  12     ISSN:  1617-7940     ISO Abbreviation:  Biomech Model Mechanobiol     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-16     Completed Date:  2014-05-30     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  101135325     Medline TA:  Biomech Model Mechanobiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  941-63     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Anisotropy
Biomechanical Phenomena
Fibrillar Collagens / chemistry
Finite Element Analysis
Humans
Image Processing, Computer-Assisted
Models, Biological
Optic Disk / physiology*
Sclera / anatomy & histology,  physiology*
Stress, Mechanical
X-Ray Diffraction
Grant Support
ID/Acronym/Agency:
EY01765/EY/NEI NIH HHS; EY02120/EY/NEI NIH HHS; EY021500/EY/NEI NIH HHS; P30 EY001765/EY/NEI NIH HHS; R01 EY002120/EY/NEI NIH HHS; R01 EY021500/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Fibrillar Collagens
Comments/Corrections

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