| Scintigraphic study on the distribution of radiolabeled cis-diamminedichloroplatinum (II) in the tumor-bearing rabbit: a comparison between intra-arterial injection with lipiodol and intravenous injection. | |
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MedLine Citation:
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PMID: 8153369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To compare the distribution of cis-diamminedichloroplatinum (II) (CDDP) on scintigraphic images between intra-arterial injection with lipiodol and intravenous injection, we obtained serial scintigraphic images using radiolabeled CDDP (Pt-195m CDDP), which had a high specific activity (7.4 x 10(6) Bq [200 microCi]/mg-CDDP), in the rabbit VX-2 tumor system. A dose of 9.25 x 10(6) Bq (250 microCi) of Pt-195m CDDP was injected at one shot via an ear vein, while 7.4 x 10(6) Bq (200 microCi of Pt-195m CDDP mixed with 1 ml of lipiodol was injected at one shot via a saphenous artery. Mean pixel count, which was corrected for the total dose injected, in the arterially injected tumor always exceeded than that in the intravenously injected tumor. Pt-195m CDDP uptake by the rabbit tumor at 2 hr was 7.8% of the total injected dose with intravenous injection and 16.0% with intra-arterial injection. These data suggest that intra-arterial injection with lipiodol is a more useful method to increase CDDP uptake by tumors than intra-venous injection. |
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Authors:
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M Kataoka; M Kawamura; Y Nishiyama; T Fujii; H Mogami; H Itoh; K Akuta; M Akaboshi; K Kawai; K Hamamoto |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Radiation medicine Volume: 11 ISSN: 0288-2043 ISO Abbreviation: Radiat Med Publication Date: 1993 Nov-Dec |
Date Detail:
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Created Date: 1994-05-09 Completed Date: 1994-05-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8412264 Medline TA: Radiat Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 247-50 Citation Subset: IM |
Affiliation:
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Department of Radiology, Ehime University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cisplatin / administration & dosage, pharmacokinetics* Female Hindlimb Infusions, Intra-Arterial Infusions, Intravenous Injections, Intra-Arterial Injections, Intravenous Iodized Oil / administration & dosage Neoplasm Transplantation Neoplasms, Experimental / radionuclide imaging* Platinum / diagnostic use Rabbits Radioisotopes / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes; 15663-27-1/Cisplatin; 7440-06-4/Platinum; 8001-40-9/Iodized Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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