Document Detail

Scintigraphic study on the distribution of radiolabeled cis-diamminedichloroplatinum (II) in the tumor-bearing rabbit: a comparison between intra-arterial injection with lipiodol and intravenous injection.
MedLine Citation:
PMID:  8153369     Owner:  NLM     Status:  MEDLINE    
To compare the distribution of cis-diamminedichloroplatinum (II) (CDDP) on scintigraphic images between intra-arterial injection with lipiodol and intravenous injection, we obtained serial scintigraphic images using radiolabeled CDDP (Pt-195m CDDP), which had a high specific activity (7.4 x 10(6) Bq [200 microCi]/mg-CDDP), in the rabbit VX-2 tumor system. A dose of 9.25 x 10(6) Bq (250 microCi) of Pt-195m CDDP was injected at one shot via an ear vein, while 7.4 x 10(6) Bq (200 microCi of Pt-195m CDDP mixed with 1 ml of lipiodol was injected at one shot via a saphenous artery. Mean pixel count, which was corrected for the total dose injected, in the arterially injected tumor always exceeded than that in the intravenously injected tumor. Pt-195m CDDP uptake by the rabbit tumor at 2 hr was 7.8% of the total injected dose with intravenous injection and 16.0% with intra-arterial injection. These data suggest that intra-arterial injection with lipiodol is a more useful method to increase CDDP uptake by tumors than intra-venous injection.
M Kataoka; M Kawamura; Y Nishiyama; T Fujii; H Mogami; H Itoh; K Akuta; M Akaboshi; K Kawai; K Hamamoto
Related Documents :
2687199 - Clinical experience with ioversol for angiography.
2956289 - Ischemic optic neuropathy secondary to intracarotid infusion of bcnu.
6985789 - Selective intra-arterial vasopression in fusion for upper gastrointestinal tract hemorr...
11917979 - Early thrombolysis in stroke due to basilar artery occlusion.
6614959 - Intra-arterial reserpine for raynaud's syndrome. systemic reactions without therapeutic...
8153369 - Scintigraphic study on the distribution of radiolabeled cis-diamminedichloroplatinum (i...
20175109 - Role of sonography in the diagnosis and treatment of a large iatrogenic pseudoaneurysm ...
21377889 - Trans-catheter closure of the native aortic valve with an amplatzer(®) occluder to tre...
20470689 - Vertebral artery aneurysms and cervical arteriovenous fistulae in patients with neurofi...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Radiation medicine     Volume:  11     ISSN:  0288-2043     ISO Abbreviation:  Radiat Med     Publication Date:    1993 Nov-Dec
Date Detail:
Created Date:  1994-05-09     Completed Date:  1994-05-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8412264     Medline TA:  Radiat Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  247-50     Citation Subset:  IM    
Department of Radiology, Ehime University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cisplatin / administration & dosage,  pharmacokinetics*
Infusions, Intra-Arterial
Infusions, Intravenous
Injections, Intra-Arterial
Injections, Intravenous
Iodized Oil / administration & dosage
Neoplasm Transplantation
Neoplasms, Experimental / radionuclide imaging*
Platinum / diagnostic use
Radioisotopes / diagnostic use
Reg. No./Substance:
0/Radioisotopes; 15663-27-1/Cisplatin; 7440-06-4/Platinum; 8001-40-9/Iodized Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mid-dose rate intracavitary therapy for cervical cancer with a Selectron: a preliminary report.
Next Document:  Aneurysm arising from the petrous portion of the internal carotid artery: case report.