Document Detail


Scintigraphic study on the distribution of radiolabeled cis-diamminedichloroplatinum (II) in the tumor-bearing rabbit: a comparison between intra-arterial injection with lipiodol and intravenous injection.
MedLine Citation:
PMID:  8153369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To compare the distribution of cis-diamminedichloroplatinum (II) (CDDP) on scintigraphic images between intra-arterial injection with lipiodol and intravenous injection, we obtained serial scintigraphic images using radiolabeled CDDP (Pt-195m CDDP), which had a high specific activity (7.4 x 10(6) Bq [200 microCi]/mg-CDDP), in the rabbit VX-2 tumor system. A dose of 9.25 x 10(6) Bq (250 microCi) of Pt-195m CDDP was injected at one shot via an ear vein, while 7.4 x 10(6) Bq (200 microCi of Pt-195m CDDP mixed with 1 ml of lipiodol was injected at one shot via a saphenous artery. Mean pixel count, which was corrected for the total dose injected, in the arterially injected tumor always exceeded than that in the intravenously injected tumor. Pt-195m CDDP uptake by the rabbit tumor at 2 hr was 7.8% of the total injected dose with intravenous injection and 16.0% with intra-arterial injection. These data suggest that intra-arterial injection with lipiodol is a more useful method to increase CDDP uptake by tumors than intra-venous injection.
Authors:
M Kataoka; M Kawamura; Y Nishiyama; T Fujii; H Mogami; H Itoh; K Akuta; M Akaboshi; K Kawai; K Hamamoto
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Radiation medicine     Volume:  11     ISSN:  0288-2043     ISO Abbreviation:  Radiat Med     Publication Date:    1993 Nov-Dec
Date Detail:
Created Date:  1994-05-09     Completed Date:  1994-05-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8412264     Medline TA:  Radiat Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  247-50     Citation Subset:  IM    
Affiliation:
Department of Radiology, Ehime University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cisplatin / administration & dosage,  pharmacokinetics*
Female
Hindlimb
Infusions, Intra-Arterial
Infusions, Intravenous
Injections, Intra-Arterial
Injections, Intravenous
Iodized Oil / administration & dosage
Neoplasm Transplantation
Neoplasms, Experimental / radionuclide imaging*
Platinum / diagnostic use
Rabbits
Radioisotopes / diagnostic use
Chemical
Reg. No./Substance:
0/Radioisotopes; 15663-27-1/Cisplatin; 7440-06-4/Platinum; 8001-40-9/Iodized Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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