Document Detail


Scintigraphic measurements of canine ileocolonic transit. Direct and indirect effects of eating.
MedLine Citation:
PMID:  3758614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eight dogs were equipped with ileal catheters, 50 cm proximal to the ileocolonic junction, and serosal electrodes at 5, 25, 55, 100, and 150 cm. Transit was assessed by injecting a bolus of 99mTc-diethylenetriamine pentaacetic acid through the ileal catheter and following isotope movements by serial, 4-min scintiscans. Isotope was injected in separate studies: during phase I of an interdigestive myoelectrical cycle, 10 min before a meal, and or 2 or 4 h after a meal (600 ml, 385 kcal, thickened with 4 g guar). At another time, mouth-to-colon transit of the same meal was measured by labeling it with 111In-diethylenetriamine pentaacetic acid and scanning at hourly intervals for 11 h. Transit of isotope through the terminal ileum and entry into the colon was characteristically erratic; long periods of immobility were interspersed with sudden "bolus" movements. In the fasting studies, most sudden movements occurred while phase III (migrating motor complex) of the interdigestive myoelectrical cycle migrated through the last 50 cm of ileum. Passage of a single migrating motor complex through the terminal ileum propelled about one-half the dose of isotope into the colon; complete clearance of the ileum required two or more migrating motor complexes. Immediately after the meal, ileal movements increased transiently; however, these were followed by a period of quiescence. Overall, the time for 50% of the counts to enter the colon was not different when isotope was injected 10 min before the meal from when the injection was made 2 h postprandially (207 +/- 16 min and 162 +/- 25 min, respectively). However, transit of isotope injected 4 h postprandially was significantly faster (91 +/- 13 min). In the fed state, some bolus movements could be related to specific patterns of ileal motility; however, the majority occurred during apparently random "fed-type" motility. In part II, meal marker accumulated faster in the colon after 3-4 h, suggesting that the rapid ileocecal transit at 4 h postcibal was due to increased flow of chyme through the ileum at this time.
Authors:
R C Spiller; M L Brown; S F Phillips; F Azpiroz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  91     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-11-07     Completed Date:  1986-11-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1213-20     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Colon / physiology*,  radionuclide imaging
Dogs
Eating
Female
Gastrointestinal Motility*
Ileum / physiology*,  radionuclide imaging
Grant Support
ID/Acronym/Agency:
AM32121/AM/NIADDK NIH HHS; AM34988/AM/NIADDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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