| Scintigraphic evaluation of Zenker's diverticulum. | |
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MedLine Citation:
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PMID: 13680198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Zenker's diverticulum (ZD) is a rare pathology, with a prevalence of between 0.01% and 0.11%. Definitive diagnosis of ZD can be accomplished by contrast radiographic examination (barium oesophagogram, BE); oesophageal manometry (ME) is recommended mainly for those patients suffering from dysphagia and/or gastro-oesophageal reflux. The aims of the present study were to assess whether oropharyngo-oesophageal scintigraphy (OPES) is able (a) to visualise ZD and (2) to demonstrate the corresponding alteration in the swallowing phases. We studied 16 patients (nine male, seven female, mean age 67.4 years), and 17 healthy volunteers (ten male, seven female, mean age 53 years) as a control group. All the patients underwent ME, BE and OPES. Nine patients underwent surgery and six of them were re-evaluated after 6 months. We administered 10 ml of water with 37 MBq of technetium-99m colloid through a straw, acquiring 480 sequential images (0.125 s/frame for a total of 60 s) with the patient standing in front of the gamma camera in the 80 degrees right anterior oblique position. Two static images were performed at the end of the dynamic phase, before and after ingestion of 100 ml of unlabelled water to evaluate the presence of inflammation (persistence of radioactivity in the diverticulum or oesophagus). Study of the sequential scintigraphic images and time-activity curves permitted both qualitative (diverticulum visualisation, multiple deglutitions, reflux, presence of inflammation) and quantitative analyses [oral, pharyngeal and oesophageal transit times and retention indexes, tracheal aspiration percentage] of swallowing disorders. OPES showed a good correlation with the results of other diagnostic techniques usually performed in patients with this pathology, and especially with ME in the evaluation of oropharyngeal phase disorders. Furthermore, OPES is a sensitive and simple technique that is well tolerated and entails a low irradiation dose for patients. |
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Authors:
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Venanzio Valenza; Germano Perotti; Daniela Di Giuda; Gioacchino Castrucci; Giuseppe Celi; Gennaro Restaino |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Validation Studies Date: 2003-09-09 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 30 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-05 Completed Date: 2004-10-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 1657-64 Citation Subset: IM |
Affiliation:
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Institute of Nuclear Medicine, Policlinico A Gemelli, Catholic University of Sacred Heart, Rome, Italy. vvalenza@rm.unicatt.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Deglutition Disorders / diagnosis, etiology, radionuclide imaging* Esophagus / abnormalities, radionuclide imaging* Female Humans Male Middle Aged Pharynx / abnormalities, radionuclide imaging* Reproducibility of Results Sensitivity and Specificity Zenker Diverticulum / complications, diagnosis, radionuclide imaging* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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