| Scintigraphic assessment of cardiac adrenergic innervation in patients with essential hypertension. | |
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MedLine Citation:
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PMID: 1715467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the regional cardiac adrenergic innervation in patients with essential hypertension (EHT), simultaneous iodine-123 metaiodobenzylguanidine ([123I]MIBG) and thallium-201 (201Tl) myocardial imagings were performed in five patients with EHT, seven patients with hypertrophic cardiomyopathy (HCM), and seven normal subjects. Short axial images at rest were divided into five segments: anterior, septal, posterior, lateral, and apical segments. Percent regional uptake (%RU) of 201Tl except the septal segment in patients with EHT showed no significant difference. However, the %RU of [123I]MIBG at posterior, lateral, and apical segments was significantly lower than that at anterior and septal segments in EHT. This intraimage heterogeneity of [123I]MIBG was also observed in HCM. These results suggest that there is a difference in regional adrenergic innervation of the left ventricle with myocardial hypertrophy. |
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Authors:
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Y Fujiwara; M Hamada; Y Shigematsu; T Sumimoto; K Hamamoto; K Hiwada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 17 Suppl 2 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1991 |
Date Detail:
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Created Date: 1991-10-01 Completed Date: 1991-10-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S148-50 Citation Subset: IM |
Affiliation:
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2nd Department of Internal Medicine, Ehime University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Iodobenzylguanidine Adrenergic Fibers / metabolism Cardiomyopathy, Hypertrophic / radionuclide imaging* Female Humans Hypertension / radionuclide imaging* Iodine Radioisotopes / diagnostic use Iodobenzenes / diagnostic use Male Middle Aged Sympatholytics / diagnostic use Thallium Radioisotopes / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Sympatholytics; 0/Thallium Radioisotopes; 77679-27-7/3-Iodobenzylguanidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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