Document Detail

Scientific comment. Basic science of Dupuytren's disease.
MedLine Citation:
PMID:  1284015     Owner:  NLM     Status:  MEDLINE    
At a cellular level, the major phenomenon in Dupuytren's contracture is an increase in proliferating fibroblasts, rather than an alteration in the type of fibroblasts. The collagen and glycosaminoglycan changes observed in the tissues of Dupuytren's contracture are likely to be secondary to changes in fibroblast density. Oxygen free radicals released from narrowed microvessels and from the fibroblasts themselves may play a role in stimulating fibroblast proliferation. Messina's experiments with continuous distraction and the success of limited fasciotomy indicate a role for physical forces in the pathogenesis of Dupuytren's contracture. The mechanism whereby physical events stimulate biochemical changes are undetermined, but preliminary investigations suggest that electrical fields and ion channels may be important. The future of Dupuytren's contracture rests with the delineation of these chemical and physical processes and their application and rigorous testing in the clinical setting.
G A Murrell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annales de chirurgie de la main et du membre supérieur : organe officiel des sociétés de chirurgie de la main = Annals of hand and upper limb surgery     Volume:  11     ISSN:  1153-2424     ISO Abbreviation:  Ann Chir Main Memb Super     Publication Date:  1992  
Date Detail:
Created Date:  1993-04-08     Completed Date:  1993-04-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9011039     Medline TA:  Ann Chir Main Memb Super     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  355-61     Citation Subset:  IM    
Division of Orthopedic surgery, Duke University NC, Durham.
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MeSH Terms
Cell Division
Dupuytren Contracture / epidemiology,  pathology*,  physiopathology
Fibroblasts / pathology*
Free Radicals
Ischemia / physiopathology
Reg. No./Substance:
0/Free Radicals; 11062-77-4/Superoxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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