Document Detail


Scientific and clinical aspects of the use of cidofovir in recurrent respiratory papillomatosis.
MedLine Citation:
PMID:  18502519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Cidofovir is the most contemporary adjuvant treatment for recurrent respiratory papillomatosis (RRP) and its use is increasing. Cidofovir is potentially harmful. Otolaryngologists should understand the science of cidofovir and review the current published data on the effects of this therapy.
METHOD: Pubmed was searched using the terms cidofovir and papillomatosis. Comparisons were made between published articles.
RESULTS: Thirteen articles were identified between 1998 and 2006, representing the treatment of 142 patients. Cidofovir did result in a significant improvement of papillomatous lesions in the majority (60%) of patients despite the use of different regimes of cidofovir administration. There was no unifying protocol in use. A partial response was demonstrated in 29% of patients. 7.5% had no response however, an additional 3.5% patients were lost to follow-up. No malignant change was reported.
CONCLUSION: Cidofovir does appear to be effective in improving the outcome of patients with RRP. There are no reports of malignant transformation despite concerns raised by toxicology studies.
Authors:
A J Donne; M P Rothera; J J Homer
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-05-27
Journal Detail:
Title:  International journal of pediatric otorhinolaryngology     Volume:  72     ISSN:  0165-5876     ISO Abbreviation:  Int. J. Pediatr. Otorhinolaryngol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-10     Completed Date:  2008-11-05     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8003603     Medline TA:  Int J Pediatr Otorhinolaryngol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  939-44     Citation Subset:  IM    
Affiliation:
University Department of Otolaryngology and Head and Neck Surgery, Manchester Royal Infirmary, UK. ajdonne@doctors.org.uk
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / therapeutic use*
Cytosine / analogs & derivatives*,  therapeutic use
Humans
Neoplasm Recurrence, Local
Organophosphonates / therapeutic use*
Papilloma / drug therapy*,  virology
Papillomavirus Infections / complications,  drug therapy*
Respiratory Tract Neoplasms / drug therapy*,  virology
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Organophosphonates; 71-30-7/Cytosine; JIL713Q00N/cidofovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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