Document Detail


Science to practice: what does MR oxygenation imaging tell us about human breast cancer hypoxia?
MedLine Citation:
PMID:  20032129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The paradoxical relationship between blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging and breast cancer hypoxia challenges our current understanding of what we believe is happening to erythrocytes in tumors. The ability of air breathing R2* measurements to reflect tissue hypoxia appears to be tumor type-specific, which should prompt further exploration of this image contrast mechanism in both human and animal tumors.
Authors:
Anwar Padhani
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Radiology     Volume:  254     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-3     Citation Subset:  AIM; IM    
Affiliation:
Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex HA6 2RN UK. anwar.padhani@stricklandscanner.org.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / blood*,  physiopathology
Breast Neoplasms / blood*,  diagnosis*,  physiopathology
Erythrocytes / physiology*
Female
Humans
Magnetic Resonance Imaging / methods*
Oxygen / blood*
Phenotype
Radiopharmaceuticals / diagnostic use
Tomography, Emission-Computed / methods*
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 7782-44-7/Oxygen
Comments/Corrections
Comment On:
Radiology. 2010 Jan;254(1):110-8   [PMID:  20032145 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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