Document Detail


The science of stroke: mechanisms in search of treatments.
MedLine Citation:
PMID:  20670828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review focuses on mechanisms and emerging concepts that drive the science of stroke in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing evidence has led to the realization that the biological processes underlying stroke are driven by the interaction of neurons, glia, vascular cells, and matrix components, which actively participate in mechanisms of tissue injury and repair. As new targets are identified, new opportunities emerge that build on an appreciation of acute cellular events acting in a broader context of ongoing destructive, protective, and reparative processes. The burden of disease is great, and its magnitude widens as a role for blood vessels and stroke in vascular and nonvascular dementias becomes more clearly established. This review then poses a number of fundamental questions, the answers to which may generate new directions for research and possibly new treatments that could reduce the impact of this enormous economic and societal burden.
Authors:
Michael A Moskowitz; Eng H Lo; Costantino Iadecola
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neuron     Volume:  67     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-08-23     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-98     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Vessels / pathology,  physiopathology
Cost of Illness
Humans
Models, Biological
Risk Factors
Stroke / economics,  etiology,  pathology,  therapy*
Grant Support
ID/Acronym/Agency:
R01 NS034179/NS/NINDS NIH HHS; R01 NS034179-16/NS/NINDS NIH HHS; R01 NS037853/NS/NINDS NIH HHS
Comments/Corrections
Erratum In:
Neuron. 2010 Oct 6;68(1):161

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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