| Sciatic nerve of diabetic rat treated with epoetin delta: effects on C-fibers and blood vessels including pericytes. | |
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MedLine Citation:
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PMID: 20547541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In diabetes mellitus (DM) reduced motor and sensory properties of peripheral nerves are linked with the dysfunction of neural vasculature. We investigated C-fibers and microvessels of sciatic nerve of normal, DM, and DM + epoetin delta-treated rats. C-fibers immunoreactive for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase (TH), epoetin receptor (EpoR), and common beta receptor subunit of the interleukin 3 receptor (IL-3Rbeta) were present in all rats, whereas in DM and epoetin-treated rats C-fibers also showed neuronal (nNOS) and inducible (iNOS) nitric oxide synthases. The cross-sectional area of CGRP-positive C-fibers was decreased in DM, but it recovered after epoetin treatment. In all conditions, vascular endothelium showed scarce immunolabeling for endothelial nitric oxide synthase (eNOS); the profound immunoreactivity for eNOS, EpoR, and IL-3Rbeta was in pericytes. Some perivascular autonomic nerves were damaged and IL-3Rbeta positive. Findings are discussed in terms of declined sensory conduction velocity in DM, its improvement after epoetin treatment, and the possible vascular contribution to these phenomena. |
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Authors:
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Andrzej Loesch; Helen Tang; Mary A Cotter; Norman E Cameron |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-13 |
Journal Detail:
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Title: Angiology Volume: 61 ISSN: 1940-1574 ISO Abbreviation: Angiology Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-08 Completed Date: 2010-10-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 651-68 Citation Subset: IM |
Affiliation:
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Research Department of Inflammation, University College London Medical School, Royal Free Campus, London, UK. aloesch@ntlworld.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcitonin Gene-Related Peptide / metabolism Cytokine Receptor Common beta Subunit / metabolism Diabetes Mellitus, Experimental / physiopathology* Diabetic Neuropathies / physiopathology* Erythropoietin, Recombinant / pharmacology*, therapeutic use Immunohistochemistry Male Microvessels / drug effects, pathology* Nerve Fibers, Unmyelinated / drug effects*, pathology, ultrastructure Neural Conduction / drug effects, physiology Nitric Oxide Synthase Type I / metabolism Nitric Oxide Synthase Type II / metabolism Pericytes / drug effects, pathology*, physiology Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects Sciatic Nerve / cytology, drug effects*, pathology* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Cytokine Receptor Common beta Subunit; 0/Erythropoietin, Recombinant; 0/epoetin delta; 83652-28-2/Calcitonin Gene-Related Peptide; EC 1.14.13.39/Nitric Oxide Synthase Type I; EC 1.14.13.39/Nitric Oxide Synthase Type II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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