| Schwann-like cells from human melanocytes and their fate in sciatic nerve injury. | |
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MedLine Citation:
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PMID: 21753712 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We induced human melanocyte dedifferentiation to Schwann cell-like cells in vitro by a combination of forskolin, neuregulin-β1, neurotrophin-3, platelet-derived growth factor-aa, basic fibroblast growth factor, laminin, and heparin. Cultured human melanocytes constitutively expressed neural cell and melanocyte markers but melanocyte-specific marker, including microphthalmia-associated transcription factor and tyrosinase, expression was selectively lost after induction. In the sciatic nerve injury site, the induced cells were engrafted and closely aligned to axons and P0-expressing myelin sheaths, whereas uninduced cells were not colocalized with axons and myelin sheaths and reexpressed melanocyte-specific tyrosinase activity in vivo. Human melanocytes lose their melanocyte phenotype and transdifferentiate into Schwann cells under specific induction conditions and display their Schwann cell phenotype after transplantation to injured sciatic nerve tissue. |
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Authors:
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Guang Fan Chi; Dae-Wook Kim; Mei Hua Jiang; Kang Jun Yoon; Youngsook Son |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroreport Volume: 22 ISSN: 1473-558X ISO Abbreviation: Neuroreport Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 603-8 Citation Subset: IM |
Affiliation:
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aDepartment of Genetic Engineering, College of Life Science and Graduate School of Biotechnology, Kyung Hee University, Yong In, Korea bResearch Institute, Cell & Bio Inc., Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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