Document Detail

Schwangerschafts protein 1 (SP1) adds little to the age-related detection of fetal Down syndrome in the first trimester of pregnancy.
MedLine Citation:
PMID:  9826903     Owner:  NLM     Status:  MEDLINE    
Schwangerschafts Protein 1 (SP1), being a placental protein appearing in the maternal circulation early in pregnancy, has been investigated as a potential marker for Down syndrome in the first trimester. Our study compared SP1 levels in 15 pregnancies with a Down syndrome fetus and 97 matched controls. Although the median MoM in Down syndrome pregnancies (0.49) was lower than in controls, its use as a marker added very little to the detection rate above the maternal age alone.
L H Kornman; L P Morssink; K A Ten Hoor; B T De Wolf; M D Kloosterman; J R Beekhuis; A Mantingh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  18     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-28     Completed Date:  1999-01-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1086-90     Citation Subset:  IM    
Groningen University Hospital, Department of Obstetrics and Gynaecology, The Netherlands.
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MeSH Terms
Biological Markers / blood*
Down Syndrome / blood,  diagnosis*
Gestational Age
Pregnancy Trimester, First
Pregnancy-Specific beta 1-Glycoproteins / analysis*
Prenatal Diagnosis / methods*
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; 0/Pregnancy-Specific beta 1-Glycoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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