| School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial. | |
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MedLine Citation:
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PMID: 12671149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The cohort consisted of 328 very low birth weight infants (600-1250 g birth weight) who were enrolled in the low-dose prophylactic indomethacin prevention trial and were intraventricular hemorrhage (IVH) negative at 6 postnatal hours. The objective was to determine the effects of both IVH and indomethacin on cognitive, language, and achievement performance at 8 years of age. METHODS: The cohort was divided into 4 subgroups for analysis: indomethacin plus IVH, indomethacin no IVH, saline plus IVH, and saline with no IVH. The children were evaluated prospectively at 8 years of age with a neurologic assessment, history of school performance, and a battery of cognitive, academic, behavioral, and functional assessments. RESULTS: Children in both IVH groups had more cerebral palsy; more hearing impairment; lower daily living skills scores; lower IQ, vocabulary, and reading and mathematics achievement test scores; and greater educational resource needs. With logistic regression analyses grade 3 to 4 IVH, periventricular leukomalacia and/or ventriculomegaly, male gender, maternal education, and language spoken in the home contributed to outcomes. No effects of indomethacin or gestational age were identified. CONCLUSIONS: Although biological factors including IVH, ventriculomegaly, and periventricular leukomalacia contribute significantly to school age outcomes among very low birth weight survivors at 8 years of age, social and environmental factors including maternal level of education and primary language spoken in the home are also important contributors to outcome. |
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Authors:
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Betty R Vohr; Walter C Allan; Michael Westerveld; Karen C Schneider; Karol H Katz; Robert W Makuch; Laura R Ment |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatrics Volume: 111 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-02 Completed Date: 2003-04-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e340-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Brown Medical School, Providence, Rhode Island, USA. betty_vohr@brown.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Hemorrhage
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prevention & control* Cerebral Palsy / epidemiology Cerebral Ventricles / drug effects*, pathology* Child Cohort Studies Developmental Disabilities / epidemiology Female Hearing Loss / epidemiology Humans Indomethacin / therapeutic use* Infant Infant, Newborn Infant, Very Low Birth Weight* / physiology, psychology Intelligence Tests / statistics & numerical data Leukomalacia, Periventricular / epidemiology Male Needs Assessment / statistics & numerical data Prospective Studies Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
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NS27116/NS/NINDS NIH HHS; RR 06022/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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