Document Detail

School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial.
MedLine Citation:
PMID:  12671149     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The cohort consisted of 328 very low birth weight infants (600-1250 g birth weight) who were enrolled in the low-dose prophylactic indomethacin prevention trial and were intraventricular hemorrhage (IVH) negative at 6 postnatal hours. The objective was to determine the effects of both IVH and indomethacin on cognitive, language, and achievement performance at 8 years of age. METHODS: The cohort was divided into 4 subgroups for analysis: indomethacin plus IVH, indomethacin no IVH, saline plus IVH, and saline with no IVH. The children were evaluated prospectively at 8 years of age with a neurologic assessment, history of school performance, and a battery of cognitive, academic, behavioral, and functional assessments. RESULTS: Children in both IVH groups had more cerebral palsy; more hearing impairment; lower daily living skills scores; lower IQ, vocabulary, and reading and mathematics achievement test scores; and greater educational resource needs. With logistic regression analyses grade 3 to 4 IVH, periventricular leukomalacia and/or ventriculomegaly, male gender, maternal education, and language spoken in the home contributed to outcomes. No effects of indomethacin or gestational age were identified. CONCLUSIONS: Although biological factors including IVH, ventriculomegaly, and periventricular leukomalacia contribute significantly to school age outcomes among very low birth weight survivors at 8 years of age, social and environmental factors including maternal level of education and primary language spoken in the home are also important contributors to outcome.
Betty R Vohr; Walter C Allan; Michael Westerveld; Karen C Schneider; Karol H Katz; Robert W Makuch; Laura R Ment
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  111     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-02     Completed Date:  2003-04-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e340-6     Citation Subset:  AIM; IM    
Department of Pediatrics, Brown Medical School, Providence, Rhode Island, USA.
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MeSH Terms
Cerebral Hemorrhage / prevention & control*
Cerebral Palsy / epidemiology
Cerebral Ventricles / drug effects*,  pathology*
Cohort Studies
Developmental Disabilities / epidemiology
Hearing Loss / epidemiology
Indomethacin / therapeutic use*
Infant, Newborn
Infant, Very Low Birth Weight* / physiology,  psychology
Intelligence Tests / statistics & numerical data
Leukomalacia, Periventricular / epidemiology
Needs Assessment / statistics & numerical data
Prospective Studies
Regression Analysis
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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