| Schnitzler syndrome with cold-induced urticaria. | |
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MedLine Citation:
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PMID: 21886751 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Schnitzler syndrome encompasses monoclonal gammopathy, urticaria, inflammation, recurrent fever, bone pain and arthralgia, with occasional lymphadenopathy and/or hepatosplenomegaly. It is a rare condition with approximately 100 cases reported in the literature. To our knowledge, this is the first reported case of cold-induced physical urticaria with Schnitzler syndrome. MAIN OBSERVATIONS: A 43-year-old woman presented to an allergy and immunology clinic with a 7 year history of chronic urticaria, angioedema with anaphylaxis, monoclonal gammopathy and bone pain. Her urticaria was triggered by cooler temperatures and an ice cube test for cold induced urticaria was positive. In spite of aggressive therapies this patient remains symptomatic. CONCLUSIONS: Schnitzler syndrome is under-recognized, particularly variants of the classical description of Schnitzler syndrome. Other diseases, especially those of hematologic origin, should be ruled out. This condition is largely refractory to conventional therapies, although novel treatments, such as interleukin-1 receptor inhibitor, may show promise. |
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Authors:
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Anil Kurian; Jason K Lee; Peter Vadas |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of dermatological case reports Volume: 4 ISSN: 1898-7249 ISO Abbreviation: J Dermatol Case Rep Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-09-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101493700 Medline TA: J Dermatol Case Rep Country: Poland |
Other Details:
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Languages: eng Pagination: 50-3 Citation Subset: - |
Affiliation:
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Department of Medicine, McMaster University, Hamilton, Ontario, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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