| Schizotypal, schizoid and paranoid characteristics in the biological parents of social anhedonics. | |
| | |
MedLine Citation:
|
PMID: 20452676 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Mounting evidence suggests that social anhedonia may be a marker of genetic liability for schizophrenia-spectrum pathology. To examine this hypothesis, we conducted a study of severity of schizotypal, schizoid and paranoid pathology (i.e., Cluster A personality disorders) in the biological parents of individuals with high levels of social anhedonia and healthy controls. Eighty-six individuals with social anhedonia, 89 healthy controls and their biological parents were recruited from a large community. Structured clinical interviews were conducted to obtain Cluster A diagnoses and symptom ratings for parents. The biological parents of socially anhedonic probands had elevated rates of Cluster A disorders (24%) compared with the parents of control probands (12%). Post hoc analyses revealed that these group differences were the result of elevated rates of diagnoses in the fathers of social anhedonic probands, but not the mothers. This finding was replicated when Cluster A symptoms were examined dimensionally. These findings are consistent with the hypothesis that social anhedonia is a promising indicator of the genetic vulnerability to schizophrenia-spectrum pathology. The unexpected findings of elevated pathology in fathers, but not mothers of socially anhedonic probands, require further exploration. |
| | |
Authors:
|
Alex S Cohen; Lindsay C Emmerson; Monica C Mann; Courtney B Forbes; Jack J Blanchard |
Related Documents
:
|
22445156 - 'a real man smells of tobacco smoke'-chinese youth's interpretation of smoking imagery ... 22704796 - Neural basis of learning and preference during social decision-making. 22393416 - From social network (centralized vs. decentralized) to collective decision-making (unsh... 22835146 - Different points of a continuum? cross sectional comparison of the current and pre-cont... 21516966 - Adolescents' undernutrition and its determinants among in-school communities of ambo to... 6863586 - Comparative analysis of parent-child interactions with language-disordered and linguist... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-05-08 |
Journal Detail:
|
Title: Psychiatry research Volume: 178 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
|
Languages: eng Pagination: 79-83 Citation Subset: IM |
Affiliation:
|
Department of Psychology, Louisiana State University, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
MH51240/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Aberrant regulation of endogenous ouabain-like factor in bipolar subjects.
Next Document: Determinants of work outcome in neuroleptic-resistant schizophrenia and schizoaffective disorder: co...