| Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier. | |
| | |
MedLine Citation:
|
PMID: 15603948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Schizophyllan having folate-appendages was synthesized from native schizophyllan through NaIO(4)-oxidation and the subsequent reductive amination in aqueous ammonia followed by amido-coupling with folic acid. The resulting folate-appended schizophyllan can form stable complex with poly(dA), show specific affinity toward folate binding protein, and mediate effective antisense activity in cancer cells. |
| | |
Authors:
|
Teruaki Hasegawa; Tomohisa Fujisawa; Shuichi Haraguchi; Munenori Numata; Ryouji Karinaga; Taro Kimura; Shiro Okumura; Kazuo Sakurai; Seiji Shinkai |
Related Documents
:
|
7127748 - Semiautomated system for simultaneous assays of serum vitamin b12 and folic acid in ser... 3630968 - Intestinal absorption, liver uptake, and excretion of 3h-folic acid in folic acid-defic... 15346778 - Response of zooplankton and phytoplankton communities to creosote-impregnated douglas f... 15139378 - Hysterothylacium winteri sp. n. (nematoda: anisakidae), a parasite of chilean rock cod,... 11162428 - Chimeras of delta6-fatty acid and delta8-sphingolipid desaturases. 14656608 - Two derivative spectrophotometric methods for the simultaneous determination of lovasta... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry letters Volume: 15 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2005 Jan |
Date Detail:
|
Created Date: 2004-12-17 Completed Date: 2005-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
|
Languages: eng Pagination: 327-30 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, Graduate School of Engineering, Kyushu University, Fukuoka 812-8581, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Base Sequence Carrier Proteins / chemical synthesis, pharmacology Folic Acid / chemistry*, pharmacology Humans KB Cells Oligonucleotides, Antisense / pharmacology* Receptors, Cell Surface Sizofiran / chemistry*, pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Carrier Proteins; 0/Oligonucleotides, Antisense; 0/Receptors, Cell Surface; 0/folate-binding protein; 59-30-3/Folic Acid; 9050-67-3/Sizofiran |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tubulin-polymerization inhibitors derived from thalidomide.
Next Document: Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug des...