Document Detail

Schizophrenic patients without neuropsychological deficits: subgroup, disease severity or cognitive compensation?
MedLine Citation:
PMID:  12379446     Owner:  NLM     Status:  MEDLINE    
Some schizophrenic patients do not show clinically relevant cognitive deficits. The question remains whether this represents the existence of an etiologically different subgroup, a general effect of disease severity or whether their cognitive deficits do not reach a clinical threshold due to a greater cognitive compensation ('brain reserve') capacity. A group of 23 out of 118 first onset patients was identified as cognitively normal (CN). The cognitive profile of these patients was compared with that of 45 healthy controls. Next these patients were compared with the cognitively impaired (CI) patients on obstetric complications (OCs), premorbid adjustment, age at onset, Positive and Negative Syndrome Scale ratings, social functioning and substance abuse. In addition both groups were compared on intelligence and educational level as indirect indicators of cognitive compensation capacity. There were no differences in OCs, premorbid adjustment, age at onset, psychopathology or substance abuse between the two patient groups. There was a significant difference in social functioning, which is a consequence rather than a cause of cognitive deficits. However, the CN patients scored significantly higher on measures of intelligence and educational level than the CI patients. This suggests that a difference in cognitive compensation capacity could explain the existence of a CN patient group.
Esther A E Holthausen; Durk Wiersma; Margriet M Sitskoorn; Ron Hijman; Peter M Dingemans; Aart H Schene; Robert J van den Bosch
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Psychiatry research     Volume:  112     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-15     Completed Date:  2003-04-07     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
Department of Psychiatry, University Hospital Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands.
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MeSH Terms
Cognition Disorders / classification,  diagnosis*,  etiology,  psychology
Educational Status
Neuropsychological Tests*
Psychiatric Status Rating Scales / statistics & numerical data
Psychotic Disorders / classification,  diagnosis,  etiology,  psychology
Schizophrenia / classification,  diagnosis*,  etiology
Schizophrenic Psychology*
Social Adjustment

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