| Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype. | |
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MedLine Citation:
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PMID: 22357348 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls.MethodWe recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ). Using enzyme-linked immunosorbent assay (ELISA) techniques, we measured peripheral levels of interleukin (IL)-1β, IL-6, IL-8 and tumour necrosis factor (TNF)-α. These immune parameters were compared in schizophrenia with childhood trauma, schizophrenia without childhood trauma and healthy controls. RESULTS: Patients with childhood trauma had higher levels of IL-6 and TNF-α than patients without trauma and healthy controls, and TNF-α levels correlated with the extent of the trauma. Patients with no trauma had similar immune profiles to controls. CONCLUSIONS: Childhood trauma drives changes, possibly epigenetic, that generate a pro-inflammatory phenotype. |
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Authors:
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U Dennison; D McKernan; J Cryan; T Dinan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-23 |
Journal Detail:
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Title: Psychological medicine Volume: - ISSN: 1469-8978 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254142 Medline TA: Psychol Med Country: - |
Other Details:
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Languages: ENG Pagination: 1-7 Citation Subset: - |
Affiliation:
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Department of Psychiatry, University College Cork, Cork, Ireland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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