Document Detail


Schizophrenia and the corpus callosum: developmental, structural and functional relationships.
MedLine Citation:
PMID:  7840887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several empirical and theoretical connections exist between schizophrenia and the corpus callosum: (1) disconnection symptoms resemble certain psychotic phenomena; (2) abnormal interhemispheric transmission could explain typically schizophrenic phenomena; (3) cases of psychosis have been found in association with complete and partial agenesis of the callosum; (4) experimental neuropsychology with schizophrenic patients has revealed abnormal patterns of interhemispheric transfer; (5) studies using magnetic resonance imaging have shown abnormal callosal dimensions in schizophrenic patients. The evidence in support of these links is discussed critically. Novel neuropsychological approaches in the study of information transfer in the visual modality between the cerebral hemispheres, consistent with callosal hyperconnectivity in schizophrenic patients but not matched psychiatric controls are highlighted. Some suggestions for further work including integrating functional and structural measures are offered.
Authors:
A S David
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Behavioural brain research     Volume:  64     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-03-08     Completed Date:  1995-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  203-11     Citation Subset:  IM    
Affiliation:
Department of Psychological Medicine, King's College Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Attention / physiology
Brain Mapping
Cerebral Cortex / physiopathology*
Corpus Callosum / abnormalities,  physiopathology*
Delirium, Dementia, Amnestic, Cognitive Disorders / physiopathology*,  psychology
Dominance, Cerebral / physiology*
Humans
Neural Pathways / physiopathology
Neuropsychological Tests
Schizophrenia / physiopathology*
Schizophrenic Psychology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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