Document Detail

Schizophrenia past clozapine: what works?
MedLine Citation:
PMID:  23277242     Owner:  NLM     Status:  MEDLINE    
Clozapine is superior to other antipsychotic drugs for treatment of refractory schizophrenia. However, its use has been limited by its potentially serious adverse effects. There is little guidance on the management of patients who discontinue clozapine for reasons such as lack of response, intolerance, or noncompliance. The literature was searched for studies on the efficacy of antipsychotics that replaced clozapine in such patients. The search revealed 15 papers, which were evaluated in this article. Olanzapine was the most tested alternative to clozapine with most of the studies reporting positive outcome, especially in patients with less severe illness and those who stop clozapine for reasons other than poor response. Other antipsychotics were not adequately tested in this manner. We concluded that in patients who discontinue clozapine, considering a trial of olanzapine would be worthwhile.
Feras Ali Mustafa
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  33     ISSN:  1533-712X     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-06-12     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-8     Citation Subset:  IM    
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MeSH Terms
Antipsychotic Agents / adverse effects,  therapeutic use*
Benzodiazepines / therapeutic use*
Clozapine / adverse effects,  therapeutic use*
Drug Substitution*
Evidence-Based Medicine
Prospective Studies
Randomized Controlled Trials as Topic
Retrospective Studies
Schizophrenia / diagnosis,  drug therapy*
Schizophrenic Psychology*
Treatment Outcome
Reg. No./Substance:
0/Antipsychotic Agents; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; J60AR2IKIC/Clozapine
Erratum In:
J Clin Psychopharmacol. 2014 Jun;34(3):343

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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