| Is a Schizo-Obsessive Subtype Associated With Cognitive Impairment?: Results From a Large Cross-sectional Study in Patients With Psychosis and Their Unaffected Relatives. | |
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MedLine Citation:
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PMID: 23274292 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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ABSTRACT: The current study investigated whether candidate cognitive endophenotypes may be used to validate a schizo-obsessive subtype. Using within-subject random effect regression analyses and cross-trait cross-relative analyses, we evaluated the association between obsessive-compulsive symptoms (OCSs) and cognitive performance in 984 patients with nonaffective psychosis (22.5% with OCSs), 973 unaffected siblings (7.7% with OCSs), 851 parents (4.2% with OCSs), and 573 controls (4.5% with OCSs). No significant within-subject associations between OCSs and cognitive functioning were found for patients and siblings. Severity of OCSs was associated with worse set-shifting ability in parents and worse processing speed in controls, but effect sizes were small (0.10 and 0.05 respectively). Cross-trait cross-relative analyses yielded no significant results. Contrary to our expectations, neither within-subject analyses nor cross-relative analyses yielded a clear association between OCSs and cognitive performance. Results do not support a schizo-obsessive subtype associated with cognitive impairment. |
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Authors:
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Julia H Meijer; Marije Swets; Soleil Keeman; Dorien H Nieman; Carin J Meijer; |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of nervous and mental disease Volume: 201 ISSN: 1539-736X ISO Abbreviation: J. Nerv. Ment. Dis. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375402 Medline TA: J Nerv Ment Dis Country: United States |
Other Details:
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Languages: eng Pagination: 30-5 Citation Subset: AIM; IM |
Affiliation:
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*Academic Medical Centre University of Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands; and †Arkin Mental Health and Addiction Treatment Centre, Amsterdam, the Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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