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Is a Schizo-Obsessive Subtype Associated With Cognitive Impairment?: Results From a Large Cross-sectional Study in Patients With Psychosis and Their Unaffected Relatives.
MedLine Citation:
PMID:  23274292     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT: The current study investigated whether candidate cognitive endophenotypes may be used to validate a schizo-obsessive subtype. Using within-subject random effect regression analyses and cross-trait cross-relative analyses, we evaluated the association between obsessive-compulsive symptoms (OCSs) and cognitive performance in 984 patients with nonaffective psychosis (22.5% with OCSs), 973 unaffected siblings (7.7% with OCSs), 851 parents (4.2% with OCSs), and 573 controls (4.5% with OCSs). No significant within-subject associations between OCSs and cognitive functioning were found for patients and siblings. Severity of OCSs was associated with worse set-shifting ability in parents and worse processing speed in controls, but effect sizes were small (0.10 and 0.05 respectively). Cross-trait cross-relative analyses yielded no significant results. Contrary to our expectations, neither within-subject analyses nor cross-relative analyses yielded a clear association between OCSs and cognitive performance. Results do not support a schizo-obsessive subtype associated with cognitive impairment.
Julia H Meijer; Marije Swets; Soleil Keeman; Dorien H Nieman; Carin J Meijer;
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nervous and mental disease     Volume:  201     ISSN:  1539-736X     ISO Abbreviation:  J. Nerv. Ment. Dis.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375402     Medline TA:  J Nerv Ment Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  30-5     Citation Subset:  AIM; IM    
*Academic Medical Centre University of Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands; and †Arkin Mental Health and Addiction Treatment Centre, Amsterdam, the Netherlands.
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