Document Detail

Schizandrin reverses memory impairment in rats.
MedLine Citation:
PMID:  17705144     Owner:  NLM     Status:  MEDLINE    
The present study investigated the effect of schizandrin, a component of the fruit of Schizandra chinesis Baill (Fructus Schizandrae), on memory impairment in rats. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, markedly impaired spatial memory in an eight-arm radial maze. A higher dose of scopolamine (3 mg/kg, i.p.) also impaired the passive avoidance response. Schizandrin (1 and 10 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of spatial memory. Similarly, schizandrin (1 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of the passive avoidance response. Moreover, in mice, schizandrin (1 and 10 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M(1) receptor agonist. Taken together these findings suggest that schizandrin reverses scopolamine-induced memory impairment, in part, by enhancing cholinergic function, and that schizandrin might be useful for treating memory deficits.
Nobuaki Egashira; Kouji Kurauchi; Katsunori Iwasaki; Kenichi Mishima; Kensuke Orito; Ryozo Oishi; Michihiro Fujiwara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  22     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-03     Completed Date:  2008-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 John Wiley & Sons, Ltd.
Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan.
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MeSH Terms
Avoidance Learning / drug effects
Cyclooctanes / chemistry,  pharmacology*
Dose-Response Relationship, Drug
Lignans / chemistry,  pharmacology*
Maze Learning / drug effects
Memory Disorders / chemically induced,  prevention & control*
Molecular Structure
Muscarinic Antagonists / pharmacology
Oxotremorine / pharmacology
Polycyclic Compounds / chemistry,  pharmacology*
Rats, Wistar
Schisandra / chemistry
Reg. No./Substance:
0/Cyclooctanes; 0/Lignans; 0/Muscarinic Antagonists; 0/Polycyclic Compounds; 51-34-3/Scopolamine; 70-22-4/Oxotremorine; 7432-28-2/schizandrin

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