Document Detail


Schistosomiasis and pregnancy.
MedLine Citation:
PMID:  17336160     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Currently, schistosomes infect approximately 40 million women of child-bearing age, yet little is known about schistosome-associated morbidity in pregnant women and their offspring. Animal models indicate a deleterious effect of schistosome infection on maternal, fetal and neonatal outcomes. Case reports have documented maternal infection in association with poor birth outcomes, and two observational studies indicate that maternal schistosome infection might be associated with decreased birth weight. Rigorously identifying and quantifying the impact of schistosome infection on pregnancy outcomes with well-designed observational and treatment studies are crucial for improving birth outcomes in schistosome-endemic areas. In addition, studies that address the safety of praziquantel during pregnancy could lead to further adoption of the recent informal recommendation by the World Health Organization to treat schistosome-infected pregnant and lactating women.
Authors:
Jennifer F Friedman; Priya Mital; Hemal K Kanzaria; G Richard Olds; Jonathan D Kurtis
Publication Detail:
Type:  Journal Article; Review     Date:  2007-03-01
Journal Detail:
Title:  Trends in parasitology     Volume:  23     ISSN:  1471-4922     ISO Abbreviation:  Trends Parasitol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966034     Medline TA:  Trends Parasitol     Country:  England    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
Affiliation:
Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA. jennifer_friedman@brown.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Genitalia, Female / parasitology
Humans
Mice
Morbidity
Placenta / parasitology
Praziquantel / adverse effects*,  therapeutic use
Pregnancy
Pregnancy Complications, Parasitic / epidemiology*
Pregnancy Outcome / epidemiology
Schistosoma / drug effects,  physiology
Schistosomiasis / drug therapy,  epidemiology*
Schistosomicides / adverse effects*,  therapeutic use
Chemical
Reg. No./Substance:
0/Schistosomicides; 55268-74-1/Praziquantel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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