Document Detail

Schistosoma mansoni: ultrastructure of adults from mice treated with oxamniquine.
MedLine Citation:
PMID:  6499999     Owner:  NLM     Status:  MEDLINE    
The in vivo effects of a single oral dose (50 mg/kg) of oxamniquine on the ultrastructure of Schistosoma mansoni were investigated. In male worms, severe disruption of the tegument and gastrodermis took place, and extensive extracellular spaces developed between the cells of the internal tissues. Elimination of the damaged worms was associated with complete tegumental breakdown and encapsulation by host cells. A small proportion of females showed similar drug-induced changes and were also eliminated. In the residual females, no drug-induced morphological damage was observed even after a second dose of oxamniquine. However, these females became much reduced in size, and regression of the organs of the reproductive system took place. It is suggested that such regressive changes resulted from discontinued male stimulation rather than the direct effect of oxamniquine.
I Popiel; D A Erasmus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental parasitology     Volume:  58     ISSN:  0014-4894     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1984-12-31     Completed Date:  1984-12-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  254-62     Citation Subset:  IM    
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MeSH Terms
Extracellular Space
Genitalia, Female / ultrastructure
Liver / parasitology
Microscopy, Electron
Muscles / ultrastructure
Nervous System / ultrastructure
Nitroquinolines / therapeutic use*
Organoids / ultrastructure
Oxamniquine / pharmacology,  therapeutic use*
Schistosoma mansoni / drug effects,  ultrastructure*
Schistosomiasis / drug therapy*,  parasitology
Reg. No./Substance:
0/Nitroquinolines; 21738-42-1/Oxamniquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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