Document Detail


Schistosoma mansoni: temporal distribution of radioselenium-labelled schistosomula in lungs of mice during the first two weeks of infection.
MedLine Citation:
PMID:  6835697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The number of schistosomula in lungs was determined by compressed organ autoradiography at intervals up to 14 days after exposure of mice to 75Se-labelled cercariae by tail immersion. Probit analysis of compressed lung autoradiogram focus counts, expressed as percentages of initial infection level, yielded estimates of the average time of arrival, peak accumulation in the lungs and average time of departure of schistosomula: 4.5 +/- 0.87, 6.3 +/- 0.45 and 11 +/- 0.58 days, respectively. At peak accumulation 92 +/- 3.5% of the initial number of schistosomula were found in the lungs. It thus appears that little or no significant attrition of schistosomula occurred in the skin and, instead, that most of the 50-70% of penetrant cercariae that fail to reach adulthood are lost somewhere between the pulmonary and hepatic phases of development. Loss of 75Se label from schistosomula during the first 14 days was exponential, with an average half-life of 4.5 +/- 0.81 days. However, the high sensitivity of autoradiography tended to compensate for this rather rapid rate of label loss. It was pointed out that autoradiographic detection of schistosomula as discrete loci of radioactivity can also be expected to overcome the problem posed by the accumulation in such tissues as liver and kidney of 75Se label that has become separated from larvae.
Authors:
J R Georgi; D A Dean; B L Mangold
Related Documents :
19151197 - Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function...
6107497 - Pulmonary fat accumulation after intralipid infusion in the preterm infant.
3227007 - Measles pneumonia in a newborn.
18290257 - Therapeutic lung lavage with diluted surfactant in neonates with severe meconium aspira...
9288667 - Parathyroid hormone levels in preterm and term labor.
3661127 - Serum ferritin and iron status in mothers and newborn infants.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Parasitology     Volume:  86 (Pt 1)     ISSN:  0031-1820     ISO Abbreviation:  Parasitology     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401121     Medline TA:  Parasitology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Lung / parasitology*
Mice
Mice, Inbred Strains
Radioisotopes
Schistosoma mansoni / physiology
Schistosomiasis / parasitology*
Selenium
Time Factors
Grant Support
ID/Acronym/Agency:
N01 AI92619/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Radioisotopes; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The influence of the H-2 complex on responses to infection by Schistosoma mansoni in mice.
Next Document:  Recovery of parasites at different stages of migration following infection of rats with Schistosoma ...