| Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails. | |
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MedLine Citation:
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PMID: 19660454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Schistosomes develop successfully in susceptible snails but are encapsulated and killed in resistant ones. Mechanism(s) shaping these outcomes involves the parasites ability to evade the snail's defenses. RNA analysis from resistant (BS-90), non-susceptible (LAC2) and susceptible (NMRI) juvenile Biomphalaria glabrata to Schistosoma mansoni revealed that stress-related genes, heat shock protein 70 (Hsp 70) and reverse transcriptase (RT), were dramatically co-induced early in susceptible snails, but not in resistant/non-susceptible ones. These transcripts were, however, down regulated upon exposure to irradiated parasites although penetration behavior of irradiated vs. normal parasites were the same, indicating that Hsp 70 and RT regulation was elicited by infection and not injury. Understanding molecular events involved in stress response transcriptional regulation of Hsp 70 in juvenile snails could pave a way towards the identification of genes involved in schistosome/snail interactions. |
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Authors:
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Wannaporn Ittiprasert; Rahul Nene; André Miller; Nithya Raghavan; Fred Lewis; Jacob Hodgson; Matty Knight |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-08-04 |
Journal Detail:
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Title: Experimental parasitology Volume: 123 ISSN: 1090-2449 ISO Abbreviation: Exp. Parasitol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-09-07 Completed Date: 2009-09-18 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0370713 Medline TA: Exp Parasitol Country: United States |
Other Details:
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Languages: eng Pagination: 203-11 Citation Subset: IM |
Affiliation:
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Biomedical Research Institute, Rockville, MD 20852, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomphalaria / genetics, immunology*, parasitology* Down-Regulation / immunology Gamma Rays Gene Expression HSP70 Heat-Shock Proteins / biosynthesis*, genetics RNA-Directed DNA Polymerase / biosynthesis*, genetics Reverse Transcriptase Polymerase Chain Reaction Schistosoma mansoni / immunology, physiology*, radiation effects Transcriptional Activation / immunology |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI063480-05/AI/NIAID NIH HHS; R01 AI063480-05S1/AI/NIAID NIH HHS; R01-AI63480/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HSP70 Heat-Shock Proteins; EC 2.7.7.49/RNA-Directed DNA Polymerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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