Document Detail


Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails.
MedLine Citation:
PMID:  19660454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Schistosomes develop successfully in susceptible snails but are encapsulated and killed in resistant ones. Mechanism(s) shaping these outcomes involves the parasites ability to evade the snail's defenses. RNA analysis from resistant (BS-90), non-susceptible (LAC2) and susceptible (NMRI) juvenile Biomphalaria glabrata to Schistosoma mansoni revealed that stress-related genes, heat shock protein 70 (Hsp 70) and reverse transcriptase (RT), were dramatically co-induced early in susceptible snails, but not in resistant/non-susceptible ones. These transcripts were, however, down regulated upon exposure to irradiated parasites although penetration behavior of irradiated vs. normal parasites were the same, indicating that Hsp 70 and RT regulation was elicited by infection and not injury. Understanding molecular events involved in stress response transcriptional regulation of Hsp 70 in juvenile snails could pave a way towards the identification of genes involved in schistosome/snail interactions.
Authors:
Wannaporn Ittiprasert; Rahul Nene; André Miller; Nithya Raghavan; Fred Lewis; Jacob Hodgson; Matty Knight
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-08-04
Journal Detail:
Title:  Experimental parasitology     Volume:  123     ISSN:  1090-2449     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-09-07     Completed Date:  2009-09-18     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-11     Citation Subset:  IM    
Affiliation:
Biomedical Research Institute, Rockville, MD 20852, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomphalaria / genetics,  immunology*,  parasitology*
Down-Regulation / immunology
Gamma Rays
Gene Expression
HSP70 Heat-Shock Proteins / biosynthesis*,  genetics
RNA-Directed DNA Polymerase / biosynthesis*,  genetics
Reverse Transcriptase Polymerase Chain Reaction
Schistosoma mansoni / immunology,  physiology*,  radiation effects
Transcriptional Activation / immunology
Grant Support
ID/Acronym/Agency:
R01 AI063480-05/AI/NIAID NIH HHS; R01 AI063480-05S1/AI/NIAID NIH HHS; R01-AI63480/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/HSP70 Heat-Shock Proteins; EC 2.7.7.49/RNA-Directed DNA Polymerase
Comments/Corrections

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