Document Detail

Schistosoma mansoni: eicosanoid production by cercariae.
MedLine Citation:
PMID:  3917929     Owner:  NLM     Status:  MEDLINE    
Cercariae of Schistosoma mansoni are stimulated to penetrate skin by certain free fatty acids. The cercariae have an active arachidonate cascade, presumably using host skin essential fatty acids as cascade precursors. Exposing cercariae to 3.3 mM linoleate for 1, 10, and 60 min resulted in production of a wide variety of eicosanoids. Using high-performance liquid chromatography, eicosanoids coeluting with prostaglandin E2, D2, and A2, leukotriene B4, and 5-hydroxyeicosatetraenoic acid standards were identified, as well as unidentified peak positions. Radioimmunoassay confirmed the presence of immunoreactive prostaglandin E1, and E2, and 5- and 15-hydroxyeicosatetraenoic acids in cercarial extracts. No eicosanoid production occurred when cercariae were exposed to 3.3 mM oleate and 1 or 330 microM linoleate. Both high-performance liquid chromatography and radioimmunoassay data indicated that cercariae regulate the production of eicosanoids through time. It is postulated that arachidonate metabolism and subsequent eicosanoid production are required for successful cercarial penetration.
A C Fusco; B Salafsky; M B Kevin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental parasitology     Volume:  59     ISSN:  0014-4894     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-03-07     Completed Date:  1985-03-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  44-50     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / metabolism
Hydroxyeicosatetraenoic Acids / biosynthesis*
Linoleic Acid
Linoleic Acids / metabolism,  pharmacology*
Oleic Acid
Oleic Acids / pharmacology
Prostaglandins E / biosynthesis*
Schistosoma mansoni / metabolism*
Grant Support
AL 02656//PHS HHS
Reg. No./Substance:
0/Arachidonic Acids; 0/Hydroxyeicosatetraenoic Acids; 0/Linoleic Acids; 0/Oleic Acids; 0/Prostaglandins E; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid; 72255-35-7/5-hydroxy-6,8,11,14-eicosatetraenoic acid; 73945-47-8/15-hydroxy-5,8,11,13-eicosatetraenoic acid; 745-65-3/Alprostadil

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