Document Detail


Schistosoma mansoni: a comparison of secreted vs nonsecreted eicosanoids in developing schistosomulae and adults.
MedLine Citation:
PMID:  2824233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have determined that developing schistosomulae and adults of Schistosoma mansoni synthesize a wide range of eicosanoids when stimulated with linoleic acid, an essential fatty acid. Developing schistosomulae secrete 64%, while adults secrete over 80% of synthesized eicosanoids. On a per milligram soluble protein basis, eicosanoid secretion is ordered as follows: adult females greater than adult males much much greater than developing schistosomulae. Together one mature adult worm pair secreted approximately 4.36 micrograms prostaglandin E, 3.41 micrograms leukotriene B4, and 15.13 micrograms 5-hydroxyeicosatetraenoic acid (HETE) as determined by radioimmunoassay (RIA). High-performance liquid chromatography (HPLC) results have determined that 15-HETE is the major HETE species secreted by adults and developing schistosomulae. The immunosuppressant roles of 15-HETE, PGE, and LTB4 are discussed in relation to a possible mechanism for S. mansoni to evade the host immune system. Adults and schistosomules of S. mansoni have evolved rather sophisticated mechanisms for evading the host immune response. These include both host antigen acquisition and antigen shedding. In addition, young schistosomes have an as yet unidentified intrinsic defense mechanism against the host immune system. We postulate that part of the defense mechanism in schistosomules and adults may involve secretion of immunosuppressant eicosanoid species.
Authors:
B Salafsky; A C Fusco
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Experimental parasitology     Volume:  64     ISSN:  0014-4894     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1987-12-31     Completed Date:  1987-12-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  361-7     Citation Subset:  IM    
Affiliation:
Department of Biomedical Science, University of Illinois College of Medicine, Rockford.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, High Pressure Liquid
Female
Host-Parasite Interactions
Hydroxyeicosatetraenoic Acids / metabolism*
Leukotriene B4 / metabolism*
Linoleic Acid
Linoleic Acids / metabolism
Male
Mice
Mice, Inbred ICR
Prostaglandins E / metabolism*
Schistosoma mansoni / growth & development*,  metabolism,  physiology
Chemical
Reg. No./Substance:
0/Hydroxyeicosatetraenoic Acids; 0/Linoleic Acids; 0/Prostaglandins E; 2197-37-7/Linoleic Acid; 71160-24-2/Leukotriene B4; 73945-47-8/15-hydroxy-5,8,11,13-eicosatetraenoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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