| Schistosoma hematobium soluble egg antigens induce proliferation of urothelial and endothelial cells. | |
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MedLine Citation:
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PMID: 11550787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bladder carcinoma accounts for 26% of reported human malignancies in Egypt, and has been strongly associated with urinary schistosomiasis. Nevertheless, the immediate role of schistosomal egg proteins in bladder carcinogenesis is unexplored. We investigated the effects of crude soluble egg antigens (SEA) of Schistosoma hematobium on urothelial cell proliferation. The proliferation of bovine endothelial Endo, human urothelial J82 and smooth muscle SMC cell lines was assessed by low-density growth assays. SEA induced proliferation of both J82 and Endo cells in a dose-dependent fashion, but not SMC. Preboiling or proteinase K treatment of SEA abolished its effect. In addition, SEA enhanced urothelial expression of B-cell translocation protein (BTG1) and human proliferating cell nuclear antigen (PCNA) mRNAs. Given the strong correlation between cell proliferation and carcinogenesis, the findings suggest that crude SEA may play some role in schistosomal bladder carcinogenesis. |
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Authors:
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M K El-Awady; Y Z Gad; Y Wen; M Eassawi; L Effat; K S Amr; S Ismail; G J Christ |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of urology Volume: 19 ISSN: 0724-4983 ISO Abbreviation: World J Urol Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-09-11 Completed Date: 2002-01-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8307716 Medline TA: World J Urol Country: Germany |
Other Details:
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Languages: eng Pagination: 263-6 Citation Subset: IM |
Affiliation:
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Human Genetics Department, National Research Center, Giza, Egypt. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Helminth / analysis, genetics, metabolism* Cattle Cell Cycle Proteins / genetics Cell Division Endothelium / cytology*, immunology Muscle, Smooth / cytology, immunology Neoplasm Proteins / metabolism Proliferating Cell Nuclear Antigen / metabolism RNA, Messenger / genetics Schistosoma haematobium / immunology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Helminth; 0/Cell Cycle Proteins; 0/Neoplasm Proteins; 0/Proliferating Cell Nuclear Antigen; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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