Document Detail


Schiff base conjugates of p-aminosalicylic acid as antimycobacterial agents.
MedLine Citation:
PMID:  16413184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Schiff base conjugates of p-aminosalicylic acid have been synthesized and characterized by elemental analysis, IR and (1)H NMR spectroscopy and cyclic voltammetry. Compounds containing hydroxyl-rich side chains show enhanced antimycobacterial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. Higher ClogP values and superior radical scavenging activities are thought to be the contributing factors for their enhanced antimycobacterial activities.
Authors:
Jayendra Patole; Dipti Shingnapurkar; Subhash Padhye; Colin Ratledge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-18
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  16     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-04-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  1514-7     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Pune, Pune 411 007, India.
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MeSH Terms
Descriptor/Qualifier:
Aminosalicylic Acid / chemical synthesis,  chemistry,  pharmacology*
Anti-Bacterial Agents / chemical synthesis,  chemistry,  pharmacology*
Free Radical Scavengers / chemical synthesis,  chemistry,  pharmacology
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Mycobacterium bovis / drug effects*
Mycobacterium smegmatis / drug effects*
Schiff Bases / chemistry*
Spectrophotometry, Infrared
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Free Radical Scavengers; 0/Schiff Bases; 65-49-6/Aminosalicylic Acid

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