| Scheduled feeding results in adipogenesis and increased acylated ghrelin. | |
| | |
MedLine Citation:
|
PMID: 21427412 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Ghrelin, known to stimulate adipogenesis, displays an endogenous secretory rhythmicity closely related to meal patterns. Therefore, a chronic imposed feeding schedule might induce modified ghrelin levels and consequently adiposity. Growing Wistar rats were scheduled-fed by imposing a particular fixed feeding schedule of 3 meals/day without caloric restriction compared to total daily control intake. After 14 days, their body composition was measured by DXA and compared to ad libitum fed controls and to rats daily intraperitoneally injected with ghrelin. Feeding patterns, circadian activity and pulsatile acylated ghrelin variations were monitored. After 14 days, rats upon an imposed feeding schedule displayed, despite an equal daily calorie intake, a slower growth rate compared to ad libitum fed controls. Moreover, scheduled-fed rats exhibiting a feeding pattern with intermittent fasting periods had a higher fat/lean ratio compared to ad libitum fed controls. Interestingly, ghrelin-treated rats also showed an increase in fat mass but the fat/lean ratio was not significantly increased compared to controls. In the scheduled-fed rats, spontaneous activity and acylated ghrelin levels were increased and associated with the scheduled meals, indicating anticipatory effects. Our results suggest that scheduled feeding, associated with intermittent fasting periods, even without a nutrient/calorie restriction on a daily basis, results in adipogenesis. This repartitioning effect is associated with increased endogenous acylated ghrelin levels. This scheduled-fed model points out the delicate role of meal frequency in adipogenesis and provides an investigation tool to clarify any effects of endogenous ghrelin without the need for ghrelin administration. |
| | |
Authors:
|
Isabelle Yvonne Verbaeys; Virginie Tolle; Quirine Swennen; Philippe Zizzari; Johan Buyse; Jacques Epelbaum; Marnix Cokelaere |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-22 |
Journal Detail:
|
Title: American journal of physiology. Endocrinology and metabolism Volume: - ISSN: 1522-1555 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Universiteit Leuven. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: AMPK rescues the angiogenic functions of endothelial progenitor cells via manganese superoxide dismu...
Next Document: Architecture of energy balance traits in emerging lines of the Collaborative Cross.