Document Detail

Schedule shifts, life quality and quantity--modeled by murine blood pressure elevation and arthropod life span.
MedLine Citation:
PMID:  555765     Owner:  NLM     Status:  MEDLINE    
During the span from 50 to 100 days and beyond, the male stroke-prone Okamoto rat develops systolic blood pressure measures in excess of 200 mm Hg. In the course of developing such a marked elevation in systolic blood pressure mean, this intermittently handled male Okamoto rat exhibits a statistically significant circadian rhythm with large amplitude. This amplitude may represent, at least in part, a response to intermittent handling; it is several times larger than the amplitude for spontaneously mesor-hypertensive (but not stroke-prone) female animals of the same age.
J Halberg; E Halberg; D K Hayes; R D Smith; F Halberg; C S Delea; R S Danielson; F C Bartter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of chronobiology     Volume:  7     ISSN:  0300-9998     ISO Abbreviation:  Int J Chronobiol     Publication Date:  1979  
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0367714     Medline TA:  Int J Chronobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  17-64     Citation Subset:  IM    
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MeSH Terms
Blood Pressure*
Cerebrovascular Disorders / genetics
Circadian Rhythm*
Heart Rate
Hypertension / physiopathology*
Life Expectancy*
Models, Biological
Quality of Life*
Rats, Inbred Strains

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