| Scent of a disorder: olfactory functioning in schizophrenia. | |
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MedLine Citation:
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PMID: 12857535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of olfactory probes to assess frontal and temporal-limbic system functioning in patients with schizophrenia has garnered increasing interest among basic and clinical investigators. Deficits in odor identification, detection threshold sensitivity, discrimination, and memory have been reported and are thought to represent a centrally mediated deficit in the processing of this information. These impairments are seen in affected probands, first-degree family members, and those at risk for developing the illness, suggesting a genetic vulnerability or predisposition to chemosensory abnormalities. The observed deficits are not explained by gender, medication use, cognitive impairment, or smoking status, and support the hypothesis of primary dysfunction in the olfactory system. Along this same line, structural abnormalities in the peripheral and central olfactory brain regions, as well as disruptions of the basic physiology of this system, have been described. The study of olfactory processing in schizophrenia has already advanced the knowledge of the neural substrate for this disorder. Because the olfactory system continuously regenerates throughout life, it allows for a unique view of an ongoing neurodevelopmental process. |
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Authors:
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Paul J Moberg; Bruce I Turetsky |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Current psychiatry reports Volume: 5 ISSN: 1523-3812 ISO Abbreviation: Curr Psychiatry Rep Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-14 Completed Date: 2003-12-09 Revised Date: 2008-09-19 |
Medline Journal Info:
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Nlm Unique ID: 100888960 Medline TA: Curr Psychiatry Rep Country: United States |
Other Details:
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Languages: eng Pagination: 311-9 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Brain Behavior Laboratory, University of Pennsylvania School of Medicine, 10th Floor Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA. moberg@bbl.med.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Olfaction Disorders / etiology*, physiopathology Olfactory Bulb / physiopathology Schizophrenia / complications* |
| Grant Support | |
ID/Acronym/Agency:
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MH59852/MH/NIMH NIH HHS; MH63381/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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